Neutralising the harmful effects of dental biofilms by bacterial replacement therapy

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Dental caries is a widespread oral disease that is costly for health services to treat, and causes pain and loss ofteeth to those affected. It is caused by production of acid by oral bacteria in biofilms on the teeth and gumscommonly known as dental plaque. Brushing teeth can reduce this problem, but many people do not do soregularly or thoroughly. This project will investigate the application of bacterial replacement therapy in theform of a lozenge containing a suitable probiotic strain to help develop an anti-caries environment within thedental plaque biofilm. The project will combine the strengths of two UK SMEs, a world class culture collectioncentre and a leading probiotics manufacturer. The project will investigate strains held within the NCIMB culturecollection for their potential to create novel biofilms to combat dental caries..