Defining the Harmful Effects of Microplastics on Gastrointestinal Health
定义微塑料对胃肠道健康的有害影响
基本信息
- 批准号:10707872
- 负责人:
- 金额:$ 37.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-22 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:Adherent CultureAffectApplications GrantsAwarenessCell LineCell RespirationChronicColonDataDoseEnvironmental HealthEpithelial CellsEpitheliumExposure toFoodFunctional disorderGastrointestinal tract structureGeneral PopulationGlycolysisGoalsHealthHealth HazardsHumanImmune systemIndividualInflammatoryInflammatory Bowel DiseasesIngestionIntestinal permeabilityIntestinesKnowledgeMaintenanceMetabolicMetabolismModelingMusOrganOrganoidsOxygenOxygen ConsumptionPathologyPathway interactionsPatientsPersonsPlanet EarthPlasticsPollutionPopulationPredispositionPrincipal InvestigatorProteinsPublic HealthResearchRiskSourceSystemTestingTight JunctionsUV Radiation ExposureWaterZebrafishcombatdysbiosisgastrointestinalgut dysbiosisgut inflammationgut microbiotahealth knowledgein vivoinsightintestinal epitheliumintestinal homeostasismetabolomemicrobial communitymitochondrial metabolismmonolayernovelparticleparticle exposurepreservationpreventprogramssystemic inflammatory response
项目摘要
Program Director/Principal Investigator: Castillo, Eliseo, F
PROJECT SUMMARY
Plastic pollution and the breakdown of plastic materials primarily into micron-sized microplastic particles (MP)
have contaminated our food and water sources, raising public health concerns. MP ingestion by humans is
now an inevitable consequence of global plastic pollution and there is a critical gap in knowledge as to how MP
impact human health (WHO). There is also an important gap in knowledge regarding how MP affect the major
direct organ of contact, the gastrointestinal (GI) tract. The studies proposed in this grant application seek to
bridge this gap in environmental health knowledge and provide insight into how MP pose a significant health
risk to the general population as well as susceptible (i.e. Inflammatory Bowel Disease; IBD) individuals. Our
preliminary data provides evidence chronic MP exposure affects the GI tract specifically causing gut dysbiosis,
low-level intestinal inflammation, and alterations in cellular metabolism. Based on our preliminary studies, we
advance a novel hypothesis that MP ingestion indeed pose a human health hazard by disrupting oxidative
metabolism in epithelial cells subsequently causing intestinal permeability, dysbiosis, and an immunometabolic
active state which could lead to intestinal inflammation. Additionally, we hypothesize MP ingestion pose a
significant health risk to individuals that have an underlying condition such as intestinal inflammation as seen in
IBD patients. The goals of this application are to investigate how MP induce cellular changes in intestinal
epithelial cells and to determine how these MP-induced changes in cellular pathways can lead to intestinal
permeability, dysbiosis and an inflammatory state. In aim 1, we will investigate the effects of varying doses and
types of MP on intestinal permeability in a zebrafish model. In Aim 2, we will determine the mechanism behind
MP induced dysbiosis and intestinal permeability. Aim 3 will delineate how an intact human intestinal tract
responds to microplastics through the use of human colonoids derived from health patients as well as IBD
patients. The information generated from this project would be a ground-breaking step with important long-term
implications in understanding how MP can affect intestinal homeostasis through modulation of epithelial barrier
function and overall human health.
项目主管/首席研究员:Castillo, Eliseo, F
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eliseo F Castillo其他文献
Bioaccumulation of Microplastics in Decedent Human Brains Assessed by Pyrolysis Gas Chromatography-Mass Spectrometry
通过热解气相色谱-质谱法评估死者大脑中微塑料的生物累积
- DOI:
10.21203/rs.3.rs-4345687/v1 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Matthew J Campen;Alex Nihart;Marcus A Garcia;Rui Liu;Marian Olewine;Eliseo F Castillo;Barry Bleske;Justin Scott;Tamara Howard;Jorge Gonzalez;Natalie Adolphi;Daniel F Gallego;E. Hayek - 通讯作者:
E. Hayek
Eliseo F Castillo的其他文献
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{{ truncateString('Eliseo F Castillo', 18)}}的其他基金
Defining the Harmful Effects of Microplastics on Gastrointestinal Health
定义微塑料对胃肠道健康的有害影响
- 批准号:
10367419 - 财政年份:2022
- 资助金额:
$ 37.02万 - 项目类别:
Defining the Harmful Effects of Microplastics on Gastrointestinal Health
定义微塑料对胃肠道健康的有害影响
- 批准号:
10260984 - 财政年份:2020
- 资助金额:
$ 37.02万 - 项目类别:
Mechanisms of Modulation of Gut Immunity by Ingested Uranium and Mixed Metal Exposures
摄入铀和混合金属暴露调节肠道免疫的机制
- 批准号:
10707527 - 财政年份:2017
- 资助金额:
$ 37.02万 - 项目类别:
Mechanisms of Modulation of Gut Immunity by Ingested Uranium and Mixed Metal Exposures
摄入铀和混合金属暴露调节肠道免疫的机制
- 批准号:
10353204 - 财政年份:2017
- 资助金额:
$ 37.02万 - 项目类别:
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