CONTROL OF NEURAL FUNCTION IN ANESTHESIA

这项研究的广泛目标是理解感觉编码在 周围神经系统和建立药物治疗 在不同类别的传入中扰乱这些密码，从而 实现可逆的、功能性选择性感觉丧失。3个具体的 目的是：1.确定外周主干的冲动模式 轴突、背根神经节(DRG)胞体和背根(DR) 由不同的生理刺激以不同的强度诱导。2.至 确定塑造这些形态的离子和代谢机制 外周不同区域的特征脉冲模式 传入器。3.利用1.和2中的知识，应用 不同药物和/或电流在沿神经的多个部位 有选择地扰乱不同功能类中的模式 传入器。 运动、感觉和伤害性感觉能力的神经学评估 将在注射了药物的老鼠的行为测试中进行 已被证明可以选择性地改变不同纤维类型的脉冲模式 以评估这些药物的不同阻滞效应。这个 结果将决定一)如何才能完全消除感觉 消灭周围神经冲动，以及II)如何正确地 神经活性药物加电流可达到的条件 这种损失具有功能选择性和临床实用性。科学的 这项工作的重要性在于它将提供明确的信息 浅谈脉冲药理学与功能性的关系 能力。这些数据将是第一个建立相对 感觉神经元根据其功能类别的敏感度 而不是根据它们的物理特性(直径， 传导速度、轨迹)。这些数据对于解释结果是必不可少的 诊断差异阻断程序在科学研究中的应用 疼痛背后的神经回路。这些指标的临床应用价值 研究表明，它们为合理的设计和 药物在周围神经系统中的应用 功能性选择性神经阻滞。这项工作的目的是带来新的 控制功能的程序，例如选择性地阻断疼痛 保留其他感觉和运动功能。或者，有选择性地 阻断运动轴突可用于减少痉挛和震颤，而不需要 对感觉的干扰。

The broad objectives of this research are to understand sensory coding in the peripheral nervous system and to establish pharmacological treatments to disrupt these codes in different classes of afferents, and thereby achieve reversible, functionally selective sensory loss. The 3 specific aims are: 1. to determine the patterns of impulses in peripheral trunk axons, in dorsal root ganglion (DRG) cell bodies, and in dorsal roots (DR) induced by different physiological stimuli at various intensities. 2. to determine the ionic and metabolic mechanisms that shape these modality characteristic impulse patterns in the different regions of the peripheral afferents. 3. to exploit the knowledge gained in 1. and 2 by applying different drugs and/or electrical current at several loci along the nerve to disrupt patterns selectively in different functional classes of afferents. Neurological evaluations of motor, sensory and nociceptive capabilities will be made in behavioral tests of rats injected with drugs that have been shown to alter impulse patterns selectively in different fiber types in order to assess the differential block effects of those drugs. The results will determine i) how sensation can be abolished without total annihilation of peripheral nerve impulses, and ii) how the proper conditions of neuroactive drugs plus electrical current can accomplish this loss with functional selectivity and clinical utility. The scientific importance of this work is that it will provide definitive information about the relationship between impulse pharmacology and functional capabilities. The data will be the first to establish the relative susceptibility of sensor neurons according to their functional class instead of according to their physical characteristics (diameter, conduction velocity, locus). Such data are essential to interpret results of diagnostic differential blocking procedures in scientific studies of the neuronal circuitry underlying pain. The clinical relevance of these studies is that they present a foundation for the rational design and application of drugs in the peripheral nervous system to accomplish functionally selective nerve blocks. The work is intended to lead to new procedures for control of function, such as selective block of pain while preserving other sensations and motor function. Alternatively, selective blockade of motor axons could be used to reduce spasm and tremor without interference with sensation.