AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在灵长类动物和人类中，肺发育的很大一部分发生在出生后，包括发育中的呼吸道的增殖和神经支配。我们记录了6个月大的猴子在出生后发育过程中暴露于臭氧（O3）加过敏原（HDMA）的气道比在过滤空气（FA）中饲养的动物上皮内神经显着减少。此外，神经在上皮中的分布也发生了改变。本研究的目的是确定吸入皮质类固醇是否可以逆转这些变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In primates and humans, a substantial portion of lung development occurs postnatally, including proliferation and innervation of the developing respiratory tract. We documented that the airways of 6 month-old monkeys exposed to ozone (O3) plus allergen (HDMA) during postnatal development had significantly fewer intraepithelial nerves than animals raised in filtered air (FA). In addition, the nerves had an altered distribution in the epithelium. The objective of this study was to determine whether inhaled corticosteroids could reverse these changes.