Does renal afferent nerve activation contribute to cardiac sympathoexcitation and decreased renal function in heart failure?

肾传入神经激活是否会导致心脏交感神经兴奋和心力衰竭时肾功能下降？

• 批准号: nhmrc : 1054619
• 负责人: Dr Lindsea Booth
• 金额: $ 20.79万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-renal-afferent-heart-failure/112408
• 关键词: Does; renal; afferent; nerve; activation

Removal of the nerves sending information between the kidneys and the brain reduces blood pressure in hypertensive patients. There is intense interest in the use of this procedure in heart failure patients, as it may reduce the harmful high level of nerve activity from the brain to the heart and kidneys. Using an experimental model of heart failure, I will determine whether this approach is beneficial in heart failure and its mechanisms of action.

切除肾脏和大脑之间传递信息的神经可以降低高血压患者的血压。人们对在心力衰竭患者中使用该程序非常感兴趣，因为它可以减少从大脑到心脏和肾脏的有害的高水平神经活动。使用心力衰竭的实验模型，我将确定这种方法是否有益于心力衰竭及其作用机制。