GENE STRUCTURE AND SEQUENCE

长期目标是利用分子生物学的工具来研究 进化中的一系列问题，神经系统的特异性， 系统，并在早期开发。 已知基因的外显子结构将 为了理解蛋白质的结构， 一组用于组装蛋白质的原始成分。 的 免疫球蛋白样结构域中小外显子的选择性剪接 的神经细胞粘附分子，N-CAM，将进行研究，以确定 如果这些可选择剪接产生新的次要同种型 罕见细胞的特异性，如果这些特异性与 大脑或机体的模式。 RNA的遗传 编辑将被研究，以确定这种新的生物学的起源。 过程

The long term goals are to use the tools of molecular biology to study a series of problems in evolution, in the specificity of the nervous system, and in early development. The exon structure of known genes will be analyzed in order to understand protein structure in terms of a simple set of primordial components that were used to assemble proteins. The alternative splicing of small exons in the immunoglobulin-like domains of the neural cell adhesion molecule, N-CAM, will be studied to determine if these alternative splices produce minor isotypes of novel specificities in rare cells, and if these specificities have to do with the patterning of the brain or the organism. The phylogeny of RNA editing will be studied to determine the origin of this novel biological process.