A microfluidic approach to study the mechanobiology of ageing blood vessels

本项目旨在研究血管内皮细胞内老化动脉硬化的影响。它使用一种独特的微流控技术探索内皮细胞发生的变化，该技术具有可调的壁硬度，以模拟老化动脉的生物物理和生化特性。预期的结果是确定控制血管内皮细胞对动脉硬化反应的细胞机制。这应该提供所需的基本知识，以帮助开发新的治疗方法，以应对与年龄有关的疾病，如心血管疾病和痴呆症。

This project aims to study the effect of the stiffening of ageing arteries in endothelial cells. It explores the changes that occur in endothelial cells using a unique microfluidic technology with tuneable wall stiffness to mimic the biophysical and biochemical properties of ageing arteries. The expected outcome is the identification of the cellular mechanisms that control endothelial responses to arterial stiffening. This should provide the fundamental knowledge required to assist in the development of new therapies to tackle age-related conditions such as cardiovascular disease and dementia.