The molecular basis of endothelial mechanotransduction through TRPV4

TRPV4 内皮力传导的分子基础

• 批准号: DE170100239
• 负责人: A/Prof Sara Baratchi
• 金额: $ 26.03万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100239
• 关键词: molecular; basis; endothelial; mechanotransduction; through

This project aims to understand how blood flow dynamics coordinate the plasma membrane localisation and interaction of the transient receptor potential vanilloid 4 (TRPV4), a candidate mechanosensitive ion channel broadly expressed in endothelium with physiological and pathological roles in the cardiovascular system, with other mechanoreceptors and the physiological relevance of these events. Blood flow haemodynamics affect cardiovascular health and morphogenesis. This project will highlight the role of TRPV4 channels in the short- and long-term adaptive responses to shear stress and will also have significant potential for application in future drug discovery.

该项目旨在了解血流动力学如何协调瞬时受体电位香草酸 4 (TRPV4) 的质膜定位和相互作用，TRPV4 是一种在内皮细胞中广泛表达的候选机械敏感离子通道，在心血管系统中具有生理和病理作用，与其他机械感受器以及这些事件的生理相关性。血流动力学影响心血管健康和形态发生。该项目将强调 TRPV4 通道在剪切应力的短期和长期适应性响应中的作用，并且还将在未来的药物发现中具有巨大的应用潜力。