Modular Vortex Fluidic Mediated Molecular Transformations

模块化涡流流体介导的分子转化

• 批准号: DP200101106
• 负责人: Prof Colin Raston AO FAA
• 金额: $ 43.48万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101106
• 关键词: Modular; Vortex; Fluidic; Mediated; Molecular

The project aims to develop the use of electric and magnetic fields to control chemical and biochemical reactions in high shear thin films under readily scalable continuous flow conditions to then be able to precisely build complex functional molecules. Depending on the orientation, strength and frequency of external electric and magnetic fields, and novel shear stress induced electric fields in solution, rates of reactions can be enhanced, with higher yields and tunable selectivity, and reduced waste and energy usage, which is not possible using traditional batch processing. This will be translated into molecular assembly line processing and the development of a new synthetic toolbox, with applications in preparing pharmaceuticals.

该项目旨在开发电场和磁场的使用，以在易于扩展的连续流动条件下控制高剪切薄膜中的化学和生化反应，从而能够精确构建复杂的功能分子。取决于外部电场和磁场的方向、强度和频率，以及溶液中的新型剪切应力诱导电场，可以提高反应速率，具有更高的产率和可调的选择性，并减少废物和能量使用，这是使用传统的分批处理不可能实现的。这将转化为分子组装线处理和开发新的合成工具箱，并应用于制备药物。