Lowering the incidence and death-rate of invasive candidiasis through probiotic bacteria in the gut.

通过肠道中的益生菌降低侵袭性念珠菌病的发病率和死亡率。

• 批准号: 133062
• 金额: $ 10.22万
• 依托单位: PROBIOTICS INTERNATIONAL LTD
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133062
• 关键词: Lowering; incidence; death; rate; invasive

Candida yeast is a common cause of infections of the mouth and the vagina, which are irritating but not life-threatening. However, if Candida enters the bloodstream it causes a dangerous disease known as invasive candidiasis (IC). About one-third of people with IC will die from it (as the Candida infects organs of the body and becomes very difficult to eradicate). IC has become more common in recent years, as a side-effect of an increase in the number of people with weakened immune systems, particularly those in hospitals undergoing treatment for other conditions (e.g. cancer chemotherapy). One-third of the population carry Candida cells in their intestine, and normally they are harmless, because good bacteria in the gut keep the Candida under control. But broad-spectrum antibiotics can destroy the good bacteria, and leave yeasts unaffected, and able to become dominant. From there, the Candida may cross the gut wall into the bloodstream. This project will use sophisticated selection methods to identify strains of good bacteria with characteristics to eliminate Candida cells from the gut; and so greatly reduce the risk of developing IC. Such strains will be incorporated into a probiotic product.

念珠菌是口腔和阴道感染的常见原因，这些感染具有刺激性，但不会危及生命。然而，如果念珠菌进入血液，就会导致一种危险的疾病，称为侵袭性念珠菌病(IC)。大约三分之一的IC患者将死于它(因为念珠菌会感染身体的器官，变得非常难以根除)。近年来，IC变得更加常见，这是免疫系统减弱的人数增加的副作用，特别是在医院接受其他疾病(如癌症化疗)治疗的人。三分之一的人在肠道中携带念珠菌细胞，通常情况下它们是无害的，因为肠道中的良好细菌可以控制念珠菌。但广谱抗生素可以摧毁有益的细菌，让酵母不受影响，并能够占据主导地位。从那里，念珠菌可能会穿过肠壁进入血液。该项目将使用复杂的选择方法来鉴定具有消除肠道念珠菌细胞特性的优良细菌菌株，从而大大降低罹患IC的风险。这些菌株将被加入到益生菌产品中。