Responsive ‘OFF-ON’ switchable anion receptors for transmembrane transport

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The project aims to develop switchable anion transporters and new assays to monitor the switchability of these compounds. Anion transport into cells has been shown to trigger cell death and so could be used as a method of killing cancer cells. However in order to do this the transporter compounds must target cancer cells specifically and not affect normal cells. Should this project be funded it will provide new fundamental knowledge on transporter design (switching transport on in cancer cells) which will be applicable to the future development of transporter-based therapeutics. It will also also provide interdisciplinary training opportunities for a PDRA, PhD and Honours students in a successful Australia-Spain collaboration.