Responsive ‘OFF-ON’ switchable anion receptors for transmembrane transport

用于跨膜运输的响应性“关-开”可切换阴离子受体

• 批准号: DP200100453
• 负责人: Prof Philip Gale
• 金额: $ 31.6万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-24 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100453
• 关键词: Responsive; OFF; switchable; anion; receptors

The project aims to develop switchable anion transporters and new assays to monitor the switchability of these compounds. Anion transport into cells has been shown to trigger cell death and so could be used as a method of killing cancer cells. However in order to do this the transporter compounds must target cancer cells specifically and not affect normal cells. Should this project be funded it will provide new fundamental knowledge on transporter design (switching transport on in cancer cells) which will be applicable to the future development of transporter-based therapeutics. It will also also provide interdisciplinary training opportunities for a PDRA, PhD and Honours students in a successful Australia-Spain collaboration.

该项目旨在开发可转换的阴离子转运蛋白和新的检测方法，以监测这些化合物的可转换性。 阴离子转运到细胞中已被证明会引发细胞死亡，因此可以用作杀死癌细胞的方法。 然而，为了做到这一点，转运蛋白化合物必须特异性靶向癌细胞，而不影响正常细胞。 如果该项目得到资助，它将提供关于转运蛋白设计（在癌细胞中打开转运）的新的基础知识，这将适用于基于转运蛋白的治疗方法的未来发展。它还将为PDRA，博士和荣誉学生提供跨学科的培训机会，并成功地与澳大利亚-西班牙合作。