Responsive ‘OFF-ON’ switchable anion receptors for transmembrane transport

该项目旨在开发可切换的阴离子转运体和新的检测方法来监测这些化合物的可切换性。阴离子转运进入细胞已被证明会引发细胞死亡，因此可以用作杀死癌细胞的一种方法。然而，为了做到这一点，转运体化合物必须专门针对癌细胞，而不影响正常细胞。如果这个项目得到资助，它将提供关于转运体设计（在癌细胞中开启转运）的新基础知识，这将适用于未来基于转运体的治疗方法的发展。它还将在澳大利亚和西班牙的成功合作中为PDRA、博士和荣誉学生提供跨学科培训机会。

The project aims to develop switchable anion transporters and new assays to monitor the switchability of these compounds. Anion transport into cells has been shown to trigger cell death and so could be used as a method of killing cancer cells. However in order to do this the transporter compounds must target cancer cells specifically and not affect normal cells. Should this project be funded it will provide new fundamental knowledge on transporter design (switching transport on in cancer cells) which will be applicable to the future development of transporter-based therapeutics. It will also also provide interdisciplinary training opportunities for a PDRA, PhD and Honours students in a successful Australia-Spain collaboration.