Selective anion transporters with therapeutic potential

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This project aims to develop compounds that can selectively facilitate the transport of anions such as chloride or bicarbonate across lipid bilayer membranes. Current generations of transporters have been shown to be un-selective, transporting protons, hydroxide or fatty acid head groups along with the anion of interest. New strategies will be developed to construct selective transporters including using encapsulating binding sites and dynamic covalent approaches to binding to produce selective systems. These transporters have potential future application as electrophysiological tools to study lipid bilayer transport processes.