Feasibility of diagnosing cardio-respiratory conditions by advanced analysis of parameters in Tidal Breathing CO2 Waveforms

通过潮式呼吸 CO2 波形参数的高级分析诊断心肺疾病的可行性

• 批准号: 133379
• 金额: $ 6.67万
• 依托单位: CAMBRIDGE RESPIRATORY INNOVATIONS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133379
• 关键词: Feasibility; diagnosing; cardio; respiratory; conditions

"Cambridge Respiratory Innovations Limited (CRiL), of Swavesey, Cambridgeshire, has been awarded a grant by Innovate UK to complete a feasibility study into an innovative new diagnostic device for chronic respiratory conditions.Currently a clinician needs to use a range of medical devices, from peak-flow meters through spirometers and pulse oximeters to scans and x-rays, to diagnose a respiratory condition. The most commonly used devices to diagnose asthma, COPD and other chronic respiratory diseases are spirometers and peak-flow meters. Both devices are difficult for patients to use, rely on forced expiratory manoeuvres, are technique dependent and measure a respiratory proxy. Adults in respiratory distress and children cannot use these devices.CRiL has developed an innovative epitaxially-grown III-V LED-based CO2 sensor which is faster, more accurate and more consistent than any existing incandescent or florescent CO2 sensor. It is not affected by condensation in the breath and is a fraction of the cost. We have developed it specifically to measure the CO2 waveform shape in normal tidal breathing to use in low-cost personal respiratory monitors. Tidal breathing CO2 (TBCO2) waveform shape analysis is an established but under-used biomarker for respiratory conditions. Whilst medical devices that measure exhaled CO2 (called capnometers) are commonplace in the operating theatre, devices that measure tidal breathing CO2 are not used in any form of respiratory disease diagnosis at the moment.This feasibility study will complete research to establish the feasibility of using CRiL's platform hardware to capture the TBCO2 waveform shape in the surgery, doctors office or clinic and use the parameters in the waveform shape to diagnose specific respiratory conditions. It will include researching the needs of the clinicians and will deliver a ""proof of concept"" device to continue the development of the technology. The main areas of focus will be the users' needs, the design inputs and the potential of the technology and dataset. The primary output from this feasibility study will be the fully-costed development plan.This feasibility study will identify whether there are any technical impediments which prevent the development of a respiratory diagnostic device based on tidal breathing CO2 measurement, whether the medical profession would support such a device, what evidence and education doctors might require to support it and whether there are any intellectual property opportunities and hurdles."

“位于剑桥郡 Swavesey 的剑桥呼吸创新有限公司 (CRiL) 获得了 Innovate UK 的资助，用于完成针对慢性呼吸系统疾病的创新型新型诊断设备的可行性研究。目前，临床医生需要使用一系列医疗设备，从峰值流量计到肺活量计和脉搏血氧计，再到扫描和 X 射线来诊断呼吸系统疾病。 诊断哮喘、慢性阻塞性肺病和其他慢性呼吸道疾病的常用设备是肺活量计和峰值流量计。这两种设备对患者来说都很难使用，依赖于用力呼气动作，依赖于技术并测量呼吸指标。患有呼吸窘迫的成人和儿童无法使用这些设备。CRiL 开发了一种创新的外延生长 III-V LED 二氧化碳传感器，速度更快、性能更强 比任何现有的白炽灯或荧光灯 CO2 传感器更准确且更一致。它不受呼吸中冷凝的影响，并且成本只是一小部分。我们专门开发它来测量正常潮式呼吸中的二氧化碳波形，以用于低成本个人呼吸监测仪。潮式呼吸 CO2 (TBCO2) 波形形状分析是一种已建立但未充分利用的呼吸状况生物标志物。虽然 测量呼出二氧化碳的医疗设备（称为二氧化碳计）在手术室中很常见，测量潮式呼吸二氧化碳的设备目前尚未用于任何形式的呼吸系统疾病诊断。这项可行性研究将完成研究，以确定使用 CRiL 的平台硬件在手术室、医生办公室或诊所捕获 TBCO2 波形形状并使用波形形状中的参数来诊断特定呼吸状况的可行性。 它将包括研究临床医生的需求，并将提供“概念验证”设备以继续技术的开发。主要关注领域是用户的需求、设计输入以及技术和数据集的潜力。该可行性研究的主要输出将是完全成本的开发计划。该可行性研究将确定是否存在任何技术障碍阻碍基于潮式呼吸的呼吸诊断设备的开发 二氧化碳测量，医学界是否会支持这种设备，医生可能需要哪些证据和教育来支持它，以及是否存在任何知识产权机会和障碍。”