HIPPOCAMPAL NEUROPLASTICITY OF INFANT STRESS

描述：最近的证据表明，动物之前 压力体验也表现出行为敏感性或过度兴奋。 在以后的测试情况下的响应性。申请人最近 证明了从巢、水坝和兄弟姐妹中分离出来的幼鼠 在生命的第一周，每天只有一个小时 导致对安非他明激发的高反应性 在成年后。申请者的主要假设是压力 生命早期经历显著改变神经元的可塑性 并导致大脑功能的永久性变化。 特别是，申请人已经证明了新生儿应激增强了LTP 从青少年那里获得的措施，而早期的研究强调 成人LTP表现为损害。申请人现建议： 检查新生儿应激对两种电生理的影响 (LTP)和神经化学(体内微透析)措施 雄性和雌性大鼠在内侧区强直前和后 穿孔通路。

DESCRIPTION: Recent evidence indicates that animals with prior stress experience also exhibit behavioral sensitivity or hyper- responsiveness in later test situations. The applicant has recently demonstrated that rat pups isolated from the nest, dam and siblings for as little as one hour per day during the first week of life results in hyperresponsivity to an amphetamine challenge administered in adulthood. The applicant's primary hypothesis is that stress experienced early in life significantly alters neuronal plasticity within the CNS and results in permanent changes in brain function. In particular, the applicant has shown that neonatal stress enhanced LTP measures obtained from juveniles while earlier studies in stressed adults showed impairment of LTP. The applicant now proposes to examine the impact of neonatal stress upon both electrophysiological (LTP) and neurochemical (in vivo microdialysis) measures obtained from both male and female rats before and after tetanization of the medial perforant pathway.