MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES

慢性病遗传流行病学模型

• 批准号: 2197460
• 负责人: SANDRA J HASSTEDT
• 金额: $ 7.63万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 1999-07-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2197460
• 关键词: alleles; chronic disease /disorder; computer data analysis; computer program /software; computer simulation; developmental genetics; epidemiology; family genetics; genetic disorder; genetic mapping; genetic markers; genetic models; genotype; human data; human population genetics; mathematical model; model design /development; pleiotropism; statistics /biometry

DESCRIPTION: The goal of the present proposal is to develop, extend, and enhance methods of likelihood analysis of pedigree data, including both segregation and linkage analysis. This will be done using PAP, the Pedigree Analysis Package, a series of Fortran programs that have been developed and modified over the past 15 years. There are four specific aims, each with two specific projects. The first aim involves developing new algorithms to model mitochondrial inheritance and to model the effect of selection. The second aim is to develop new methods of screening for multilocus effects on phenotypes and to develop simulation-based goodness-of-fit tests. The third aim is to extend current programs to implement a newer ascertainment correction scheme, and to incorporate replicate and MZ twin data. The final aim is to distribute, support, and update PAP for the scientific community, and to develop revision 5 of the entire PAP package.

描述：本提案的目标是开发、扩展和 加强系谱数据的似然分析方法，包括 分离和连锁分析。这将使用PAP、 系谱分析包，一系列Fortran程序，已经被 在过去的15年里开发和修改了。有四个具体的 目标，每个目标都有两个具体的项目。第一个目标涉及 开发新的算法来模拟线粒体遗传和 对选择效果进行建模。第二个目标是开发新的方法。 对表型的多位点效应的筛选和开发 基于模拟的拟合优度测试。第三个目标是扩展 实现较新的确知校正方案的当前程序， 并合并复制和MZ孪生数据。最终的目标是 为科学界分发、支持和更新PAP，以及 开发整个PAP包的修订版5。