MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES

慢性病遗传流行病学模型

• 批准号: 6387482
• 负责人: SANDRA J HASSTEDT
• 金额: $ 18.74万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6387482
• 关键词: alleles; chronic disease /disorder; computer data analysis; computer program /software; computer simulation; developmental genetics; epidemiology; family genetics; genetic disorder; genetic mapping; genetic markers; genetic models; genotype; human data; human population genetics; linkage mapping; mathematical model; method development; model design /development; pleiotropism; statistics /biometry

DESCRIPTION: (Adapted from investigator's abstract) This application proposes to continue to develop and distribute easy-to-use, powerful, and versatile software for likelihood analysis of family data by extending and enhancing PAP (Pedigree Analysis Package), a software package for the likelihood analysis and phenotype simulation of family data. One of the many applications of PAP, linkage analysis that is used to localize a gene within the genome, is the vital first step in the process of identifying a gene which underlies a disease. Present methods of linkage analysis require excess computer time and lack power when the disease inheritance pattern is complex. This application proposes to remedy both shortcomings. The first specific aim of this project proposes to develop, implement, and evaluate new genetic models and methodology in PAP. The general emphasis of this aim is to improve the multipoint linkage analysis methodology within PAP, by adding methodology to analyze complex traits and to make more efficient use of multipoint genetic marker data. Completion of this project will enable PAP to perform time-efficient multipoint linkage analysis either assuming or maximizing on any genetic model currently available in PAP, or using a mode-of-inheritance-free method. The second specific aim of this project proposes to enhance and support PAP. In addition to continuing to support and distribute PAP, this aim proposes to improve the portability of PAP by converting the source code from Fortran 77 to C++ and proposes to improve the ease-of-use of PAP by developing a graphical user interface. The software will be revised with particular consideration for the speed of computation, ease of use, and portability. A graphical user interface and web-based documentation will facilitate ease of use. The software will be made available through a web site allowing potential users to obtain a copy at no charge and with no delay. Questions will be answered promptly when problems of usage arise.

描述：(改编自调查人员摘要)本申请提出 继续开发和发布易于使用、功能强大且功能多样的 扩展和增强PAP的家庭数据似然分析软件 (系谱分析包)，用于似然性分析的软件包和 家系数据的表型模拟。PAP的众多应用之一， 用于在基因组内定位基因的连锁分析是 关键的第一步，在确定基因的过程中 疾病。目前的连锁分析方法需要额外的计算机时间和 当疾病遗传模式复杂时，缺乏力量。此应用程序 建议弥补这两个缺点。 该项目的第一个具体目标是开发、实施和 在PAP中评估新的遗传模型和方法。大体上强调 这一目的是为了改进PAP内的多点连锁分析方法， 通过增加方法论来分析复杂的特征并更有效地利用 多点遗传标记数据。该项目的完成将使PAP 要执行省时的多点链接分析，请假定或 最大化PAP中当前可用的任何遗传模型，或使用 无继承模式的方法。 该项目的第二个具体目标是加强和支持人民行动计划。在……里面 除了继续支持和分发PAP外，这一目标还建议 通过将源代码从Fortran 77转换到PAP来提高PAP的可移植性 C++，并建议通过开发一个图形化的 用户界面。本软件的修订将特别考虑到 计算速度、易用性和可移植性。图形用户 界面和基于Web的文档将便于使用。该软件 将通过一个网站提供，允许潜在用户获得 免费复印，不耽误时间。问题将在以下情况下及时得到答复 用法上的问题就出现了。