CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
慢性阻塞性肺疾病基因定位
基本信息
- 批准号:6538021
- 负责人:
- 金额:$ 3.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-04-01 至 2004-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Applicant's Abstract): Chronic obstructive pulmonary disease
(COPD) is a slowly progressive disorder characterized by airways obstruction
that lasts for at least several months. The two major causes of COPD are
chronic bronchitis and emphysema. Either disorder may occur with or without
airways obstruction, but airways obstruction causes impairment of lung function
leading to disability and death. COPD is a major health problem in the United
States and throughout the world, consistently ranking among the most common
causes of death in the United States. Cigarette smoking is the primary
environmental factor that increases the risk of COPD, but other environmental
factors have also been implicated. However, despite a well-established role,
environmental factors alone do not cause COPD. Symptomatic COPD develops in
only 10-20 percent of heavy cigarette smokers, probably those with a genetic
susceptibility, although common COPD susceptibility genes have yet to be
identified.
This project proposes a single specific aim: to localize, within the genome, a
COPD susceptibility gene. The strategy proposed is to apply statistical linkage
analysis to family data. Pulmonary measurements have already been collected on
159 members of 16 pedigrees and evidence supporting a COPD susceptibility gene
in these pedigrees has been obtained from segregation analysis. Each of 11,995
genetic markers, which have already been genotyped on pedigree members, will be
tested for evidence of linkage to the inferred COPD susceptibility gene.
Evidence of linkage to one or more genetic markers will identify genomic
locations of COPD susceptibility genes. The high density of markers will allow
fine-mapping of the gene.
Successful completion of this gene localization project is the necessary
prerequisite for a project to identify and characterize a COPD susceptibility
gene. Identifying a gene that when mutated increases the risk of COPD may
increase understanding of pulmonary function, as well as allowing gene-carriers
to be identified and made aware of their susceptibility.
描述(申请人摘要):慢性阻塞性肺病
慢性阻塞性肺病(COPD)是一种以气道阻塞为特征的缓慢进行性疾病
至少会持续几个月COPD的两个主要原因是
慢性支气管炎和肺气肿。任何一种疾病都可能发生,
气道阻塞,但气道阻塞导致肺功能受损
导致残疾和死亡。COPD是美国的一个主要健康问题,
国家和世界各地,一直是最常见的
美国的死亡原因。吸烟是主要的
增加COPD风险的环境因素,但其他环境因素
因素也有牵连。然而,尽管有一个既定的作用,
环境因素本身并不引起COPD。症状性COPD发生于
只有10%-20%的重度吸烟者,可能是那些有遗传缺陷的人。
易感性,尽管常见的COPD易感基因尚未被发现。
鉴定
该项目提出了一个单一的具体目标:在基因组内定位一个
COPD易感基因拟议的战略是应用统计联系
家庭数据分析。已经收集了肺部测量结果,
16个家系的159名成员和支持COPD易感基因的证据
在这些家系中,已获得分离分析。11995人
遗传标记,已经在系谱成员上进行了基因分型,将被
检测与推断的COPD易感基因的关联证据。
与一个或多个遗传标记连锁的证据将鉴定基因组
COPD易感基因的位置。标记的高密度将允许
基因的精细定位
成功地完成这个基因定位项目是必要的
识别和表征COPD易感性项目的先决条件
基因确定一个基因,当突变时,会增加患COPD的风险,
增加对肺功能的了解,并允许基因携带者
来识别和了解他们的易感性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('SANDRA J HASSTEDT', 18)}}的其他基金
Rare Variant Associations With Severe Obesity in Utah Pedigrees
犹他州谱系中与严重肥胖相关的罕见变异
- 批准号:
8733975 - 财政年份:2011
- 资助金额:
$ 3.75万 - 项目类别:
Rare Variant Associations With Severe Obesity in Utah Pedigrees
犹他州谱系中与严重肥胖相关的罕见变异
- 批准号:
8724485 - 财政年份:2011
- 资助金额:
$ 3.75万 - 项目类别:
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
慢性阻塞性肺疾病基因定位
- 批准号:
6322148 - 财政年份:2001
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES
慢性病遗传流行病学模型
- 批准号:
6387482 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
慢性病遗传流行病学模型
- 批准号:
7209028 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES
慢性病遗传流行病学模型
- 批准号:
6520779 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES
慢性病遗传流行病学模型
- 批准号:
2906495 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
慢性病遗传流行病学模型
- 批准号:
6926516 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES
慢性病遗传流行病学模型
- 批准号:
6647688 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
慢性病遗传流行病学模型
- 批准号:
7603101 - 财政年份:1999
- 资助金额:
$ 3.75万 - 项目类别:
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