Toxicity Alert Biosensor (TAB)

毒性警报生物传感器 (TAB)

• 批准号: 133777
• 金额: $ 15.94万
• 依托单位: ALTAIR MEDICAL LTD
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133777
• 关键词: Toxicity; Alert; Biosensor; TAB

"Opioids are a class of drug prescribed for pain relief or used illicitly for their euphoric effect. In 2016, 23 million prescriptions were issued for opioids in the UK. In that same year, 2,893 people died from accidental opioid overdose. In the USA, there were more than 42,000 deaths. Opioid overdose is now the largest cause of accidental death in most developed countries- far greater than road traffic accidents. Nearly all of these deaths are preventable, either through safer use of opioids or early detection of overdose and administration of a life-saving antidote.Harm from overdose isn't restricted to deaths. For every fatal overdose, there are 20-30 non-fatal overdoses resulting in ambulance call outs, hospital admissions, hospital treatment, loss of productivity and temporary or permanent disability. The estimated annual costs in the UK are in the region of £3.5bn. In the US, the estimated cost is in excess of $500bn.Closely linked to the extent of harm from opioids is the potential for misuse. Opioid users quickly develop tolerance and doses have to be increased rapidly to gain beneficial effects. As the population ages, and with rising health problems, many more patients require the need for pain relief. This has created unprecedented demand for long-term use and an explosion in rates of opioid misuse.Altair Medical Ltd is a health technology start-up company spun out of successful healthcare and IT companies based in Scotland. Our innovative technology continuously monitors patients taking opioids using a small, wireless wearable sensor paired to a smartphone. Data collected by the sensor is analysed by artificial intelligence which monitors drug usage and advises on safe timing of doses, tailored to each individual patient, to reduce the risk of overdose. Should this fail, it detects overdose and alerts first responders to administer naloxone, the powerful opioid antidote.By continuously monitoring high risk opioid users, our technology can also:* identify signs of opioid misuse and facilitate treatment* improve pain control and reduce the risk of side effects* reduce the risk of opioid interactions with other types of medication* send reports to the prescribing doctor to assist in clinical decision making* assist in determining safety for driving.All of which have the potential to dramatically lower the risk of harm from opioid use."

“阿片类药物是一类用于止痛或非法使用以达到愉悦效果的药物。2016年，英国为阿片类药物开出了2300万张处方。同年，2893人死于意外的阿片类药物过量。在美国，死亡人数超过4.2万人。阿片类药物过量现在是大多数发达国家意外死亡的最大原因--远远超过道路交通事故。几乎所有这些死亡都是可以预防的，要么是通过更安全地使用阿片类药物，要么是通过及早发现过量和服用一种救命解药。每一次致命的服药过量，就有20-30次非致命的服药过量，导致救护车出动、住院、医院治疗、生产力丧失以及暂时或永久性残疾。据估计，英国每年的成本约为35亿英镑。在美国，估计成本超过5000亿美元。与阿片类药物的危害程度密切相关的是滥用的可能性。阿片类药物使用者迅速产生耐受性，必须迅速增加剂量才能获得有益的效果。随着人口老龄化和健康问题的增加，更多的患者需要缓解疼痛。这创造了前所未有的长期使用需求和阿片类药物滥用比率的爆炸性增长。Altair Medical Ltd是一家健康技术初创公司，由苏格兰成功的医疗保健和IT公司衍生而来。我们的创新技术使用一个与智能手机配对的小型无线可穿戴传感器来持续监测服用阿片类药物的患者。传感器收集的数据由人工智能进行分析，人工智能监控药物使用情况，并为每个患者量身定做的安全剂量时机提供建议，以降低过量用药的风险。如果失败，它会检测到过量用药，并提醒急救人员使用纳洛酮，这是一种强大的阿片解毒剂。通过持续监测高风险阿片类药物使用者，我们的技术还可以：*识别阿片类药物滥用的迹象并促进治疗*改善疼痛控制并降低副作用风险*降低阿片类药物与其他类型药物相互作用的风险*向处方医生发送报告，以协助临床决策*帮助确定驾驶安全。所有这些都有可能显著降低阿片类药物使用造成的伤害风险。