EXERCISE AND DIET EFFECTS ON LACTATION PERFORMANCE

运动和饮食对哺乳表现的影响

• 批准号: 2199051
• 负责人: KATHRYN G DEWEY
• 金额: $ 22.52万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2199051
• 关键词: bioenergetics; blood chemistry; body composition; breast feeding; caloric dietary content; developmental nutrition; exercise; female; growth /development; human milk; human subject; infant human (0-1 year); lactation; nutrition related tag; prolactin; reducing diet

Many women in the U.S. desire to lose weight during the postpartum period and often turn to caloric restriction or exercise to help accomplish this goal. However, it is unknown to what extent energy balance can be altered before lactation is compromised. The goal of the proposed research is to evaluate the effect of short-term caloric restriction or exercise with caloric restriction on lactation performance. Women who are exclusively breastfeeding at 8-12 wk postpartum will be randomly assigned to one of 3 groups (N=25/group) for a period of 11 d: a) control, given 100% of energy needs; b) caloric restriction to 65% of energy needs; and c) exercise plus caloric restriction to create a similar caloric deficit as in group b. Measurements of baseline energy intake and expenditure will be used to determine initial energy needs and will serve as the basis for the diets furnished and exercise levels prescribed during the intervention. Data on milk volume and composition, plasma prolactin, maternal body composition and infant weight will be collected prior to and during the 11-d intervention period. Milk volume will be determined by 3-d test-weighing using an electronic balance. Milk samples will be collected by alternate breast expression over 24 h and analyzed for fat, lactose, protein, energy and fatty acid concentrations. Plasma prolactin levels will be determined by radioimmunoassay from blood samples collected by indwelling catheter before, during and after a breastfeeding episode. Maternal body composition will be assessed by hydrostatic weighing and deuterium dilution in respiratory water. Repeated measures analysis of variance will be used to examine the impact of the intervention. The results of this study will be useful for determining a safe minimal caloric intake during lactation for U.S. women.

许多美国女性希望在产后减肥 并经常转向热量限制或锻炼来帮助实现这一目标 目标。然而，尚不清楚能量平衡可以改变到什么程度 在哺乳受到损害之前。拟议研究的目标是 评估短期热量限制或运动的效果 热量限制对泌乳性能的影响。 专一的女性 产后 8-12 周母乳喂养将被随机分配到 3 组之一 组（N=25/组），持续 11 天：a) 对照，给予 100% 的能量 需要； b) 热量限制为能量需求的 65%； c) 运动加 热量限制以产生与 b 组类似的热量赤字。 基线能量摄入和支出的测量将用于 确定初始能量需求并将作为饮食的基础 干预期间规定的配备和运动水平。 数据于 乳汁量和成分、血浆催乳素、母体成分 婴儿体重将在 11 天之前和期间收集 干预期。奶量将通过 3 d 测试称重确定 使用电子天平。牛奶样本将由交替收集 24 小时内乳房表达并分析脂肪、乳糖、蛋白质、能量 和脂肪酸浓度。将测定血浆催乳素水平 通过留置导管采集的血液样本进行放射免疫分析 母乳喂养之前、期间和之后。 母体 将通过静压称重和氘来评估成分 稀释呼吸用水。重复测量方差分析将 用于检查干预措施的影响。 这样做的结果 研究将有助于确定安全的最低热量摄入量 美国妇女的哺乳期。