THE EFFECT OF COCKROACH ALLERGIES IN CHILDREN WITH ASTHMA

蟑螂过敏对哮喘儿童的影响

基本信息

  • 批准号:
    5205898
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

Asthma is a problem of increasing importance in the United States, especially among minority and inner-city groups. Causes for this increase in asthma are poorly defined; however, studies from many areas of the United States point to a high prevalence of sensitization to cockroach among asthmatics, especially in inner cities, but also among rural and small town residents. Skin test surveys, bronchial challenge studies, and evidence of occupational illness demonstrate the relevance of cockroach allergen to asthma. Cockroach allergen may be found in vacuumed dust from households, but a critical level beyond which sensitization or symptoms are expected is not known. The amount and nature of any cockroach allergen suspended in household air is not known. The effect of suggested cockroach control measures on allergen in household dust and air is not known. Similarly, it is not known if reduction of exposure to cockroach allergen will have an effect on lung function in cockroach-sensitive asthmatics. This proposed study will investigate several of these gaps in knowledge of cockroach allergens and their relation to asthma. Hypotheses to be tested are: (1). Simple control of cockroach population in a detached dwelling will lead to a decrease in cockroach allergen in vacuumed dust. (2). This reduction in cockroach allergen will have a detectable beneficial effect on the status of asthma in patients living in the home. A parallel group, placebo-controlled trial of the use of hydramethylnon bait stations will be used to confirm, firstly, that this intervention reduces cockroach population (as expected from the literature), and, secondly, that cockroach allergen in vacuumed dust as measured by specific monoclonal antibodies also decreases. The effect on asthma will subsequently be determined by treating, also in a parallel group, double- blinded, placebo-controlled fashion, the homes of patients with asthma and cockroach sensitivity, attempting to control for the important confounding variables, especially other indoor allergens. Sample size calculation suggests that, with methacholine reactivity as the outcome indicator, sufficient power can be achieved with a realistic sample size to detect a clinically important improvement in asthma. Proof of the efficacy of this inexpensive intervention in reducing asthma severity could have major public health implications.
哮喘在美国是一个日益重要的问题, 尤其是在少数民族和市中心群体中。增加的原因 在哮喘中的定义很差;然而,来自许多领域的研究表明, 美国指出蟑螂致敏的高流行率 在哮喘患者中,特别是在城市中心,但也在农村和 小镇居民。皮肤试验调查、支气管激发研究,以及 职业病的证据表明蟑螂 哮喘过敏原蟑螂过敏原可能存在于 家庭,但超过临界水平, 预期是未知的。任何蟑螂过敏原的数量和性质 悬浮在室内空气中的情况尚不清楚。建议蟑螂的效果 对家庭灰尘和空气中过敏原的控制措施尚不清楚。 同样,目前尚不清楚是否减少接触蟑螂过敏原, 会对蟑螂过敏性哮喘患者的肺功能产生影响。 这项拟议的研究将调查以下知识方面的几个差距 蟑螂过敏原及其与哮喘的关系待检验的假设 是: (一).在独立住宅中简单控制蟑螂数量将 导致吸尘灰尘中蟑螂过敏原减少。 (二)、这种蟑螂过敏原的减少将有一个可检测的 对生活在家中的哮喘患者的状况产生有益影响。 一项使用海美农的平行组、安慰剂对照试验 诱饵站将用于确认,首先,这种干预, 减少蟑螂数量(如文献所预期),以及, 第二,通过特异性抗体检测, 单克隆抗体也减少。对哮喘的影响将 随后通过治疗,也在平行组中,双- 设盲,安慰剂对照的方式,哮喘患者的家, 蟑螂敏感性,试图控制重要的混杂因素 变量,特别是其他室内过敏原。样本量计算 表明,以乙酰甲胆碱反应性作为结果指标, 可以用实际的样本量获得足够的功效, 哮喘的临床重要改善。证明了这种方法的有效性 降低哮喘严重程度的廉价干预措施可能具有重大意义。 公共卫生影响。

项目成果

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LARRY W WILLIAMS其他文献

LARRY W WILLIAMS的其他文献

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{{ truncateString('LARRY W WILLIAMS', 18)}}的其他基金

THE LEUKOTRIENE MODIFIER OR CORTICOSTEROID OR CORTICOSTEROID-SALMETEROL TRIAL (T
白三烯调节剂或皮质类固醇或皮质类固醇-沙美特罗试验(T
  • 批准号:
    7198481
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
Low-Dose Theophylline as Add-on Therapy in Asthma
低剂量茶碱作为哮喘的附加治疗
  • 批准号:
    6974049
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
Leukotriene Modifier/Corticosteroid/Corticosteroid Trial
白三烯调节剂/皮质类固醇/皮质类固醇试验
  • 批准号:
    6974051
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
COCKROACH ALLERGEN CONTROL TECHNIQUES
蟑螂过敏原控制技术
  • 批准号:
    6534163
  • 财政年份:
    2000
  • 资助金额:
    --
  • 项目类别:
COCKROACH ALLERGEN CONTROL TECHNIQUES
蟑螂过敏原控制技术
  • 批准号:
    6124323
  • 财政年份:
    2000
  • 资助金额:
    --
  • 项目类别:
COCKROACH ALLERGEN CONTROL TECHNIQUES
蟑螂过敏原控制技术
  • 批准号:
    6374179
  • 财政年份:
    2000
  • 资助金额:
    --
  • 项目类别:
THE EFFECT OF COCKROACH ALLERGIES IN CHILDREN WITH ASTHMA
蟑螂过敏对哮喘儿童的影响
  • 批准号:
    6099974
  • 财政年份:
    1998
  • 资助金额:
    --
  • 项目类别:
THE EFFECT OF COCKROACH ALLERGIES IN CHILDREN WITH ASTHMA
蟑螂过敏对哮喘儿童的影响
  • 批准号:
    6235393
  • 财政年份:
    1997
  • 资助金额:
    --
  • 项目类别:
FOOD HYPERSENSITIVITY IN THE PATHOGENESIS OF ATOPIC DISORDERS
特应性疾病发病机制中的食物过敏
  • 批准号:
    3738848
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PLACEBO CONTROLLED TRIAL OF NUTRAMIGEN VERSUS A MODIFIED CASEIN HYDROLYSATE
NUTRAMIGEN 与改性酪蛋白水解物的安慰剂对照试验
  • 批准号:
    3783435
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
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