FOOD HYPERSENSITIVITY IN THE PATHOGENESIS OF ATOPIC DISORDERS

特应性疾病发病机制中的食物过敏

• 批准号: 3738848
• 负责人: LARRY W WILLIAMS
• 金额: --
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3738848
• 关键词: atopic dermatitis; delayed hypersensitivity; eosinophil; food hypersensitivity; human subject; mast cell; nutrition related tag; pathologic process; placebos; serum; sign /symptom

The purpose of this study is to study the nature of cells in immediate and late phase reactions to oral food challenges and look for presence of delayed- onset reactions to foods. Hypotheses: 1. Mediators released in the serum will reflect activation of mast cells and eosinophils after, respectively, immediate and late phase reactions to oral food challenge. 2. In a negative immediate challenge, symptom scores will show no difference between placebo and active weeks during prolonged double-blind feeding of suspected foods.

本研究的目的是研究即刻中细胞的性质。 以及对口腔食物挑战的晚期反应和寻找存在 对食物的迟发性反应。假设：1.调解人 释放在血清中会反映肥大细胞的激活和 嗜酸性粒细胞分别在即刻和晚期反应后 口腔食物挑战赛。2.在消极的直接挑战中，症状 分数将显示在安慰剂周和活动周之间没有差异 长期双盲喂养可疑食物。