COCKROACH ALLERGEN CONTROL TECHNIQUES

蟑螂过敏原控制技术

• 批准号: 6124323
• 负责人: LARRY W WILLIAMS
• 金额: $ 28.48万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6124323
• 关键词: allergens; arthropod nonpollutant control; asthma; clinical research; cockroach; human subject

DESCRIPTION(adapted from the applicant's abstract): The goal of this project is to demonstrate that interventions in single family homes with cockroach infestation can successfully reduce the amount of cockroach allergen in vacuumed dust. This is important because of the demonstrated correlation of asthma severity with cockroach exposure among sensitized asthmatics. The project will use a randomized, parallel-group trial of two interventions. In the first group of homes, the investigating team will directly provide services to eradicate the cockroach population and subsequently employ a professional cleaning service to physically clean areas thought to be most contaminated with cockroach allergen. Cockroach eradication will use low- toxicity, commercially available bait stations (hydramethylnon) with targeted placement. Cleaning will consist of mopping hard floors and wet washing counter and appliance tops in the kitchen and bathroom. In the second group of homes, the team will use videotaped and written instructions to teach the occupants the techniques of cockroach control used above. The study will provide the subjects with the materials needed to eradicate cockroaches and to clean the dwelling as in the first group. A control group of asthmatics that are not cockroach sensitive will be included and will have the allergen control intervention performed by the study personnel. The outcomes measured will be: 1) reduction in cockroach populations by 2 months as measured by trapping; 2) concentration of cockroach allergen Bla g 1 in vacuumed dust primarily in the kitchen and secondarily in the bedroom and living room and; 3) asthma-related Quality of Life Score at entry and exit. The study will follow homes in both groups for 18 months to determine long-term effects of the intervention.

描述（改编自申请人的摘要）：本项目的目标 是为了证明对有蟑螂的单户家庭的干预 感染可以成功地减少蟑螂过敏原的数量， 真空吸尘这一点很重要，因为已经证明了 致敏哮喘患者中蟑螂暴露与哮喘严重程度的关系的 该项目将使用两种干预措施的随机平行组试验。在 第一组家庭，调查小组将直接提供 服务，以消除蟑螂种群，并随后聘请 专业的清洁服务，以物理清洁区域被认为是最 被蟑螂过敏原污染了消灭蟑螂将使用低- 毒性，市售诱饵站（hydramethnon）与目标 安置清洁工作包括拖硬地板和湿洗 厨房和浴室的柜台和电器台面。二组 家庭，该小组将使用录像和书面指示，教 住户使用上述的蟑螂控制技术。这项研究将 为受试者提供消灭蟑螂所需的材料， 像第一组一样打扫房间。 一组对照组的哮喘患者， 对蟑螂不敏感的人将被包括在内， 研究人员进行的对照干预。衡量的结果 将是：1）蟑螂种群减少2个月， 蟑螂变应原Bla g 1在真空吸尘器粉尘中的浓度 主要是在厨房，其次是在卧室和客厅， 3)入组和退出时的哮喘相关生活质量评分。这项研究将 跟踪两组家庭18个月，以确定长期影响， 干预。