MODELING OF SIDS IN NEONATAL SWINE
新生猪 SIDS 建模
基本信息
- 批准号:2201420
- 负责人:
- 金额:$ 25.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-09-30 至 1996-08-31
- 项目状态:已结题
- 来源:
- 关键词:afferent nerve aging autonomic nervous system axon blood chemistry blood pressure bradycardia chemoreceptors denervation disease /disorder model electrocardiography evoked potentials excitatory aminoacid ganglions heart function heart innervation heart rate heart rhythm infant animal model design /development motor neurons neurons preganglionic fiber sudden infant death syndrome swine sympathetic nervous system vagus nerve ventricular fibrillation videotape /videodisc visceral afferent nerve
项目摘要
Using neonatal swine as our animal model of sudden infant death syndrome
(SIDS), we will investigate (using both acute and chronic preparations):
1) postnatal differences in innervation of the heart by vagal and
postganglionic sympathetic motoneurons, 2) the role of cardiac
arrhythmias and the effects of selected visceral afferent stimulation in
the etiology of SIDS, 3) the effects of different combinations of
autonomic denervation of the heart on survival. In addition, chronic
animals, either sham operated or denervated, will be studied under
different conditions including such stresses as feeding, temperature
changes or hypoxia. These denervation studies will allow the
determination of the importance of innervation postnatally. The results
of the experimentally induced laterality of sympathetic and/or vagal
dominance will verify the importance of balanced innervation of the
heart. In the acute preparation we will also examine the effects of
denervation on: 1) the ventricular fibrillation threshold and 2)
responses to stimulation of visceral afferents, e.g., cardiopulmonary,
J-receptor and chemoreceptor. Finally, to examine postnatal maturation
of autonomic regulation of the heart and, therefore, of times of greatest
susceptibility to arrhythmias, we will obtain motoneurons in the
ventrolateral nucleus ambiguous in order to determine: 1) their changing
pattern of activity with age, 2) their responses to afferent inputs. and
3) whether their evoked responses are age-related. These experiments
will also supply the needed information concerning the role of cardiac
arrhythmias in SIDS as well as document the suitability of neonatal swine
as an animal model for this disease. The chronic animals will be
prepared under sterile operating conditions; vascular access ports will
be implanted for blood sampling and pressure measurements while fine wire
electrodes will be inserted into the diaphragm for monitoring of
respiratory function; the EKG will be recorded from needle electrodes.
Acute experiments will be performed under Saffan anesthesia. The
aforementioned chronic and acute experiments should supply much needed
information regarding the importance of changing autonomic regulation of
the heart in the etiology of SIDS.
用新生猪作为婴儿猝死综合征的动物模型
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PHYLLIS M GOOTMAN其他文献
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