BOVINE IGG AND INFANT COLIC

婴儿绞痛是一种病因不明的儿科疾病。 绞痛是 以过度哭闹为特征，影响了20%的美国婴儿， 无论是母乳喂养还是配方奶喂养。 肠绞痛是重要的，因为婴儿 痛苦，父母因无法安慰的哭泣而沮丧，一些婴儿虐待 死亡率，儿科医生的努力，费用和缺乏有效的治疗。 由于婴儿配方奶粉和人乳中的牛IgG（BGG）水平 相似，母乳BGG水平似乎与绞痛相关， 一项关于饮食中BGG是否可能是绞痛的主要原因的调查 本文提出 BGG是人类饮食中主要的外来免疫球蛋白 （通常为500毫克/天），并具有故意运输的独特性质， 稳定性、与Fc受体的结合和免疫调节。 体外 研究表明，BGG可能会深刻影响发育中的粘膜 免疫系统，并可能引发绞痛和某些炎症性疾病。 作为一个直接的目标，这一假设将直接由 进行双盲安慰剂对照试验， BGG和安慰剂摄入后的反应。 两名母乳喂养的婴儿 和配方奶粉喂养的婴儿将进行测试， 通过简化的哭泣日记进行评估。 母亲消费的影响 乳制品对母乳中BGG水平和母乳喂养中绞痛的影响 婴儿也将被研究。 因为初步数据显示 各种形式的结肠炎患者的血清BGG水平， 目的是确定BGG是否在乳汁诱导的 结肠炎、溃疡性结肠炎和嗜酸性胃肠炎。 这将 通过分析急性发作期间患者的血清来进行 将通过RAST测定来评估这些疾病的BGG水平。 另一个目标是更好地了解BGG是如何选择性运输的 以及BGG如何在易感个体中引起绞痛或其他疾病。 肠道FcR是否解释了BGG的选择性吸收， 使用FcR缺陷型小鼠品系在动物模型中进行研究。 如何以及 当选择性BGG转运在人体内发生时，将通过以下方法进行研究： 在妊娠的不同阶段测量乳汁和血清中BGG的水平， 哺乳期 了解摄入的牛IgG在结肠绞痛中的作用， 其他疾病可能导致更好的预防和治疗方法。 这项研究也可能为自身免疫性疾病的病因学提供见解。 疾病（类风湿性关节炎、I型糖尿病）。

Infant colic is a pediatric disorder of unknown etiology. Colic is characterized by excessive crying and it affects 20% of U.S. infants, whether breast-fed or formula-fed. Colic is important because of infant pain, parental frustration with inconsolable crying, some infant abuse mortality, pediatrician effort, expense, and lack of effective treatment. Since levels of bovine IgG (BGG) in infant formulas and human milk are comparable, and breast milk BGG levels seems to correlated with colic, an investigation of whether dietary BGG might be a major cause of colic is proposed. BGG is the major foreign immunoglobulin in the human diet (often 500 mg/day) and has unique properties of intentional transport, stability, binding to Fc receptors, and immunomodulation. In vitro studies suggest that BGG may profoundly influence the developing mucosal immune system and might initiate colic and certain inflammatory diseases. As one immediate goal, this hypothesis will be tested directly by conducting double-blind placebo-controlled trials comparing infant responses after ingestion of BGG and placebo. Both breast-fed infants and formula-fed infants will be tested and colic responses will be assessed by simplified cry diaries. The effect of maternal consumption of diary products on breast milk levels of BGG and on colic in breast-fed infants will also be studied. Since preliminary data show elevated levels of serum BGG in patients with various forms of colitis, a second goal is to determine whether BGG plays an important role in milk-induced colitis, ulcerative colitis, and eosinophilic gastroenteritis. This will be carried out by analyzing sera of patients during exacerbations of these disorders for levels of BGG will be assessed by RAST assay. Another goal is to better understand how BGG is selectively transported and how BGG may cause colic or other diseases in susceptible individuals. Whether intestinal FcR account for selective BGG absorption will be studied in an animal model using a FcR-deficient mouse strain. How and when selective BGG transport occurs i humans will be investigated by measuring milk and serum levels of BGG at various stages of pregnancy and lactation. A knowledge of the role of ingested bovine IgG in colic and other disorders may lead to better methods of prevention and treatment. This research might also provide insights into etiology of autoimmune diseases (rheumatoid arthritis, Type I diabetes).