LOW COST 62ZN/62CU GENERATOR FOR MULTI ORGAN PET IMAGING

用于多器官 PET 成像的低成本 62ZN/62CU 发生器

• 批准号: 2029741
• 负责人: JEFFREY L LACY
• 金额: $ 34.09万
• 依托单位: PROPORTIONAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-16 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2029741
• 关键词: biomedical automation; biomedical equipment development; blood flow measurement; contrast media; copper; diagnosis design /evaluation; heart circulation; heart disorder diagnosis; human subject; method development; positron emission tomography; radiocardiography; radiochemistry; radionuclides; radiopharmacology; radiotracer; zinc

DESCRIPTION (Adapted from applicant's abstract): Positron emission tomography (PET) is a superior diagnostic imaging technique in a number of important clinical areas, especially myocardial viability assessment. However this and other important PET techniques are currently relegated to a research role due to dependence upon in-hospital cyclotrons for radioisotope production with resulting high cost and potentially unresolvable regulatory issues. Proportional Technologies, Inc. (PTI) proposes to develop an automated microprocessor controlled 62Zn/62Cu generator incorporating synthesis of 62Cu-PTSM. The feasibility of such a system has been demonstrated in the Phase I project. Also, efficient radiochemical process techniques required to produce the generator economically on a daily basis will be developed. This system will be produced and supplied to three active clinical PET facilities and studies supported to establish efficacy of 62Cu-PTSM for resting myocardial perfusion imaging facilitating clinical utilization with 18F-FDG. The commercial availability of this low cost generator-produced perfusion agent along with regional distribution of 18F-FDG will make myocardial viability assessment far more widely available and economically viable. This development will set the stage for even wider applications of PET in other important areas, such as stress myocardial perfusion imaging, as well as brain and tumor perfusion studies for which 62Cu-PTSM has shown promise.

描述（改编自申请人的摘要）：正电子发射 断层扫描（PET）在许多方面是一种优越的诊断成像技术 重要的临床领域，特别是心肌活力评估。 然而，这项技术和其他重要的 PET 技术目前已被降级 由于依赖医院内回旋加速器而发挥研究作用 放射性同位素生产成本高，潜在风险大 无法解决的监管问题。 Proportional Technologies, Inc. (PTI) 提议开发一种自动化的 微处理器控制的 62Zn/62Cu 发生器结合了 62Cu-PTSM。该系统的可行性已在 一期工程。此外，高效的放射化学处理技术 每天经济地生产发电机所需的量将 发达。该系统将生产并供应给三个活跃的 支持临床 PET 设施和研究以确定疗效 62Cu-PTSM 用于静息心肌灌注成像，促进临床 18F-FDG 的利用。 这种低成本发电机生产的灌注液的商业可用性 药剂连同 18F-FDG 的区域分布将使心肌 可行性评估的应用范围更加广泛且经济上可行。 这一发展将为 PET 更广泛的应用奠定基础 在其他重要领域，例如应激心肌灌注成像， 以及 62Cu-PTSM 已用于脑和肿瘤灌注研究 表现出承诺。

项目成果

Human biodistribution and dosimetry of the PET perfusion agent copper-62-PTSM.

PET 灌注剂 Copper-62-PTSM 的人体生物分布和剂量测定。

• 发表时间: 1998
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
• 作者: Wallhaus,TR;Lacy,J;Whang,J;Green,MA;Nickles,RJ;Stone,CK
• 通讯作者: Stone,CK

Performance of a 62Zn/62Cu generator in clinical trials of PET perfusion agent 62Cu-PTSM.

• 发表时间: 2000-02
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: N. Haynes;J. Lacy;N. Nayak;C. S. Martin;D. Dai;C. J. Mathias;M. Green