Manufacturing Human Organs-on-Chips towards non-animal alternatives in drug discovery and research

在药物发现和研究中制造人体器官芯片以实现非动物替代品

• 批准号: 320183
• 金额: $ 6.32万
• 依托单位: CN BIO INNOVATIONS LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=320183
• 关键词: Manufacturing; Human; Organs; Chips; towards

Development of credible non-animal technologies is necessary before well-established animal tests can be eliminated from drug discovery, chemicals testing and basic research. Miniature devices that replicate human organ function in the laboratory, so-called "Organs-on-Chips", have already been used in the race to discover new medicines to treat viral infections and lung disease. Organs-on-Chips hold promise for broader applications where they would provide superior alternatives to animal tests by better predicting the human response to new drugs. This project will overcome important barriers to the more widespread adoption of Organs-on-Chips in research laboratories around the world by using innovative manufacturing techniques to produce low cost devices that are highly intuitive to use. The availability of Organs-on-Chips to a broader community of scientists will accelerate research in this important field, leading to less animal testing and making participation in clinical trials much safer.

在药物发现、化学品测试和基础研究中消除成熟的动物试验之前，必须开发可靠的非动物技术。在实验室中复制人体器官功能的微型设备，即所谓的“芯片上的器官”，已经被用于发现治疗病毒感染和肺部疾病的新药的竞赛中。芯片器官有望获得更广泛的应用，通过更好地预测人类对新药的反应，它们将提供比动物测试更好的替代方案。该项目将通过使用创新的制造技术来生产使用起来非常直观的低成本设备，从而克服在世界各地的研究实验室中更广泛采用芯片器官的重要障碍。芯片器官向更广泛的科学家群体提供将加速这一重要领域的研究，从而减少动物测试并使参与临床试验更加安全。