Development of miniaturized multi-organ human skin-vasculature-liver model on chip (SVLOC) for biological investigation of cross-talk of multiple organs

开发小型化多器官人体皮肤-血管-肝脏芯片模型（SVLOC），用于多器官串扰的生物学研究

• 批准号: RGPIN-2015-06165
• 负责人: SanatiNezhad, Amir
• 金额: $ 1.68万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638440
• 关键词: Development; miniaturized; multi; organ; human

Understanding the cross-talk of skin with other organs such as the respiratory, gastro-intestinal tract and particularly the liver, is of paramount importance. The chemical absorbed through skin may be metabolized at liver, while the affected liver may also influence the skin. The studies focused on investigating this cross-talk are limited and have produced misleading and contradictory results due to technical challenges. Due to the side effect of dermal There is an essential need to establish a novel biomimetic in vitro multi-organ model to investigate the cross-talk of skin with relevant organs.

了解皮肤与其他器官，如呼吸道、胃肠道，特别是肝脏的相互作用，是至关重要的。通过皮肤吸收的化学物质可能在肝脏代谢，而受影响的肝脏也可能影响皮肤。由于技术上的挑战，集中于研究这种串扰的研究是有限的，并且产生了误导性和相互矛盾的结果。由于真皮的副作用，有必要建立一种新的体外仿生多器官模型来研究皮肤与相关器官的相互作用。