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iDx-LUNG - Integrating non-invasive diagnostics into NHSE Lung Health Checks in Wessex and Yorkshire

iDx-LUNG - 将非侵入性诊断集成到威塞克斯和约克郡的 NHSE 肺部健康检查中

基本信息

批准号：
42012
负责人：
金额：
$ 434.9万
依托单位：
UNIVERSITY OF SOUTHAMPTON
依托单位国家：
英国
项目类别：
Collaborative R&D
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=42012
关键词：
iDx LUNG Integrating non invasive

项目摘要

The iDx-Lung programme brings together a consortium of academic institutions, NHS England Lung Health Checks and five commercial partners to accelerate progress in the early diagnosis of lung cancer. 7000 people from Wessex, Yorkshire and Manchester attending for lung health checks at mobile CT scanners in the community will be asked to give samples of blood, and cells collected from inside the nose, for testing. We will analyse the samples for the presence of changes that may indicate the presence of early cancer development: antibodies against cancer proteins; raised levels of cancer-related proteins; circulating DNA from cancers, and changes in the expression of genes in the cells lining the nose. All of these are tests which have been developed by different companies but never used in combination or with CT scanning, to see which might be the most efficient at finding early lung cancers. We will combine the data from all these tests into a single database with complex analytical capabilities in order to allow the partners in the consortium to visualise the results in whichever way is most appropriate and informative. By doing this we will establish the best way to select people for investigation, either for initial CT scans, or for further investigation if the CT scan findings are not clear. We hope to streamline the process of detecting cancers and reduce the NHS resources that are needed in order to find each new case.

iDx-Lung计划汇集了一个学术机构联盟，NHS英格兰肺部健康检查和五个商业合作伙伴，以加速肺癌早期诊断的进展。来自威塞克斯、约克郡和曼彻斯特的7000人在社区的移动的CT扫描仪上接受肺部健康检查，他们将被要求提供血液样本，以及从鼻子内部收集的细胞进行检测。我们将分析样本中是否存在可能表明早期癌症发展的变化：针对癌症蛋白的抗体;癌症相关蛋白水平的升高;癌症的循环DNA，以及鼻子内衬细胞中基因表达的变化。所有这些测试都是由不同的公司开发的，但从未与CT扫描结合使用，以确定哪种方法在发现早期肺癌方面最有效。我们将联合收割机将所有这些测试的数据合并到一个具有复杂分析能力的数据库中，以便让联合体中的合作伙伴以最合适和最具信息性的方式可视化结果。通过这样做，我们将建立最好的方式来选择调查的人，无论是最初的CT扫描，或进一步的调查，如果CT扫描结果不清楚。我们希望简化检测癌症的过程，减少发现每一个新病例所需的NHS资源。