Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research

项目摘要 越来越多的证据表明，早期生活和生殖事件，包括特定的怀孕， 并发症，预测未来的健康风险，包括心血管（CVD）风险因素（例如，血脂异常， 高血压、肥胖）、临床CVD事件和阻塞性肺病。越来越多的证据表明， 怀孕期间的暴露可能会影响后代的心血管和肺部健康， 生活在本申请中，我们建议加强收集传统和 新出现的心脏和肺部疾病的风险因素，并记录这些疾病的发生， 三个相关的队列：护士健康研究II（NHS-II），护士健康研究3（NHS 3）， 今日成长研究（Growing Up Today Study，GUTS）这些队列总共跟踪了188，698名个体，其中包括超过 14，000名少数族裔参与者，其中包括大量非洲裔美国人和西班牙裔美国人。队列 我还跟踪了超过65,000对母亲-成年子女，超过13,000个祖母-母亲-成年子女三合会， 和16，000多个兄弟姐妹团体;促进旨在确定代际风险的研究的资源 心血管疾病和阻塞性肺疾病的因素。两个较年轻的队列（NHS 3和GUTS）中的女性在 在生育年的中期，每年约有1 000例新怀孕。 此外，研究参与者广泛分布在美国各地，使我们能够 解决有关农村人口的问题，包括被视为边境地区的问题。拟议 这三个相关群组的基础设施活动将最终支持旨在确定 CVD（CHD、中风）和阻塞性肺病（COPD和 哮喘），以及相关的生物中间终点，从基因到地理。呢我们一起来 在四个方面作出努力：1）最大限度地利用现有资源-包括更新和维持粮食 基于地理信息系统的成分数据库和与地理有关的接触数据 (GIS)2）收集与血压的亲自收集相关联的生物样本，以及 人体测量数据，3）基于网络的移动的技术和“大数据”能力的扩展， 四是加强数据共享能力。联合收割机结合生物标记数据的能力， 最先进的移动的高分辨率测量和传统的流行病学风险因素数据， 在三个相关的世代中的世代和整个生命过程将使我们和其他人能够进行 强大的病因学和转化研究。我们的目标是保持随访和相关的质量 数据，以及扩大技术，将提供创新的层面，以队列的新的 科学发现

PROJECT SUMMARY Increasing evidence suggests that early life and reproductive events, including specific pregnancy complications, predict future health risks including cardiovascular (CVD) risk factors (e.g., dyslipidemia, hypertension, obesity), clinical CVD events, and obstructive lung disease. Similarly, increasing evidence suggests that exposures during pregnancy may affect offspring’s cardiovascular and lung health throughout life. In this application, we propose to strengthen the infrastructure necessary to collect data on traditional and emerging risk factors for heart and lung diseases and to document the occurrence of these conditions within three related cohorts: the Nurses’ Health Study II (NHS-II), the Nurses’ Health Study 3 (NHS3), and the Growing Up Today Study (GUTS). These cohorts collectively follow 188,698 individuals including more than 14,000 minority participants with large numbers of African Americans and Hispanic Americans. The cohorts also follow more than 65,000 mother-adult offspring pairs, over 13,000 grandmother-mother-adult child triads and over 16,000 sib-groups; resources that facilitate research aimed at identifying inter-generational risk factors for CVD and obstructive lung diseases. Women in the two younger cohorts (NHS3 and GUTS) are in the middle of the reproductive years, resulting in the accrual of approximately 1,000 new pregnancies per year. Furthermore, study participants are broadly distributed across the United States, giving us the ability to address questions regarding rural populations including areas considered to be Frontier. The proposed infrastructure activities in these three related cohorts will ultimately support research aimed at identifying intergenerational and early life risk factors for CVD (CHD, stroke) and obstructive lung disease (COPD and asthma), as well as of relevant biologic intermediate endpoints, from genes to geography. We will focus our efforts in four areas: 1) the maximization of existing resources – including updating and maintenance of food composition databases and geographically-linked exposure data based on geographical information systems (GIS), 2) the collection of biological specimens tied to an in-person collection of blood pressure and anthropometric data, 3) the expansion of web-based mobile technology and “Big Data” capabilities for the cohorts, and 4) strengthening our capability for data sharing. The ability to combine biomarker data, state-of- the-art mobile high-resolution measures, and traditional epidemiologic risk factor data, collected across generations and throughout the life-course in three related cohorts will enable us and others to conduct powerful etiologic and translational research. Our goal is to maintain the quality of follow-up and associated data, as well as to broaden the technologies that would provide innovative dimensions to the cohort for novel scientific discovery.