CORE--VIROLOGY CORE LABORATORY

核心--病毒学核心实验室

• 批准号: 3769096
• 负责人: MICHAEL F PARA
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3769096
• 关键词: AIDS; AIDS /HIV diagnosis; AIDS /HIV test; HIV infections; biomarker; biomedical facility; cooperative study; human immunodeficiency virus; human subject; immunologic assay /test; tissue /cell culture; virus antigen

The purpose of this application is to demonstrate the capability of The Ohio State University AIDS Clinical Trials Unit's virology laboratory to function as one of the core Virology Laboratories for the ACTU network. This ACTG laboratory will perform the protocol virologic monitoring as mandated by the ACTG protocols and Virology Core Committee. These include HIV antigen testing, HIV cultures and the measurement and evaluation of other viral markers as diagnostic methods evolve. Participation in quality assurance programs will standardize and validate assay results. Prior experience in the performance of a large number of these assays and the maintenance of a high level of proficiency and quality control for the last three years attests to the capability of this laboratory to perform this work. The OSU ACTU virology laboratory was/is not primarily organized as a basic research laboratory doing experimental studies ut as a clinical laboratory developing standardized assays. This concept is most important in performing the protocol mandated virologic assays where the goal is providing consistently accurate results using a consensus assay on a large number of specimens. Laboratory certifications from a variety of organizations attests to achieving this goal. Nevertheless the laboratory still has performed well in the application and development of virologic assays in the clinical setting and currently participates in the on-going evaluation of new quantitative virologic culture techniques. In addition, the virology facilities were recently constructed and were built with an expansion in function expected. Thus, both space and equipment are ample to safely handle the expected increase in specimen load.

此应用程序的目的是演示 俄亥俄州立大学艾滋病临床试验小组的病毒学实验室 作为ACTU网络的核心病毒学实验室之一。 ACTG实验室将执行协议病毒学监测 由ACTG方案和病毒学核心委员会授权。这些措施包括 HIV抗原检测、HIV培养和HIV的测量和评价 随着诊断方法的发展，其他病毒标志物也在发展。参与质量管理 保证计划将标准化和验证化验结果。 有大量此类检测和检测工作的经验 保持高水平的熟练程度和质量控制 过去的三年证明了这个实验室的能力 这项工作。俄亥俄州立大学ACTU病毒学实验室是/不是主要组织的 作为基础研究实验室进行实验研究而不是作为临床 实验室开发标准化的分析方法。这个概念是最重要的 在执行协议规定的病毒学分析时，目标是 使用大范围的共识分析提供一致准确的结果 样本数量。来自多个国家的实验室认证 组织证明实现了这一目标。然而，实验室 在病毒学的应用和发展中表现出色 在临床环境中进行检测，目前正在参与正在进行的 新的定量病毒学培养技术的评价。 此外，病毒学设施是最近建造的， 预计将在功能上进行扩展。因此，无论是空间还是 设备充足，可以安全地处理预期增加的标本 装填。