CORE--VIROLOGY CORE LABORATORY

核心--病毒学核心实验室

• 批准号: 3727062
• 负责人: MICHAEL F PARA
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3727062
• 关键词: AIDS; AIDS /HIV diagnosis; AIDS /HIV test; HIV infections; biomarker; biomedical facility; cooperative study; human immunodeficiency virus; human subject; immunologic assay /test; tissue /cell culture; virus antigen

The purpose of this application is to demonstrate the capability of The Ohio State University AIDS Clinical Trials Unit's virology laboratory to function as one of the core Virology Laboratories for the ACTU network. This ACTG laboratory will perform the protocol virologic monitoring as mandated by the ACTG protocols and Virology Core Committee. These include HIV antigen testing, HIV cultures and the measurement and evaluation of other viral markers as diagnostic methods evolve. Participation in quality assurance programs will standardize and validate assay results. Prior experience in the performance of a large number of these assays and the maintenance of a high level of proficiency and quality control for the last three years attests to the capability of this laboratory to perform this work. The OSU ACTU virology laboratory was/is not primarily organized as a basic research laboratory doing experimental studies ut as a clinical laboratory developing standardized assays. This concept is most important in performing the protocol mandated virologic assays where the goal is providing consistently accurate results using a consensus assay on a large number of specimens. Laboratory certifications from a variety of organizations attests to achieving this goal. Nevertheless the laboratory still has performed well in the application and development of virologic assays in the clinical setting and currently participates in the on-going evaluation of new quantitative virologic culture techniques. In addition, the virology facilities were recently constructed and were built with an expansion in function expected. Thus, both space and equipment are ample to safely handle the expected increase in specimen load.

此应用程序的目的是展示该功能 俄亥俄州立大学艾滋病临床试验单位的病毒学实验室 作为 ACTU 网络的核心病毒学实验室之一。 该 ACTG 实验室将执行方案病毒学监测： 由 ACTG 协议和病毒学核心委员会授权。 这些包括 HIV抗原检测、HIV培养以及测量和评估 随着诊断方法的发展，其他病毒标记物也会出现。 参与质量 保证计划将标准化和验证化验结果。 之前进行过大量此类检测的经验以及 保持高水平的熟练程度和质量控制 过去三年证明了该实验室的执行能力 这项工作。 OSU ACTU 病毒学实验室主要是/不是组织起来的 作为基础研究实验室进行实验研究 ut 作为临床研究 实验室开发标准化测定。 这个概念最重要 在执行协议规定的病毒学检测时，其目标是 使用大规模共识检测提供一致准确的结果 标本数量。 各种实验室认证 组织证明已实现这一目标。 尽管如此，实验室 在病毒学的应用和发展方面仍然表现出色 临床环境中的检测，目前正在参与正在进行的 新的定量病毒学培养技术的评估。 此外，病毒学设施最近建成并 构建了预期的功能扩展。 因此，空间和 设备足以安全处理预期增加的样本 加载。