ESTABLISHMENT OF A COHORT AND CLINICAL MANAGEMENT

我们将招募一大批艾滋病毒感染者 通过联系医生了解疾病的不同阶段，适当 医疗、公共卫生和社区组织。所有人都有 已经给予书面同意，鼓励患者 参与到项目中来。将就以下事项取得同意： 注册以及临床和实验室数据的收集。 机密性将通过编码系统得到保证。我们会 然后进行初步体检并获得常规检查 参与该项目的所有患者的实验室数据。 免疫学和病毒学评估和银行用标本 将在普通临床研究中收集和分离 中心(GCRC)。这项数据和按预定计划获得的数据如下- UP访问将输入GCRC的CLINFO数据库#年 在整个研究过程中按顺序进行。这 数据库将定义我们的艾滋病毒感染的自然历史 人口。根据最初的临床和实验室研究， 患者和样本将按照特定的方案进行分类 (项目2、3和5)将评估治疗干预措施 或研究有关艾滋病毒感染的基本问题 艾滋病的发病机制。患者将可以快速访问 最先进的医疗护理。当他们出现机会性感染时， 他们将参加治疗方案，如果有的话，或者 接受标准治疗。所有信息都将包含在 数据库。

We will recruit a large population of HIV infected individuals in various stages of disease by contacting physicians, appropriate medical, public health and community organizations. All have already given written agreement to encourage patients to participate in the project. Consent will be obtained for enrollment and the collection of clinical and laboratory data. Confidentiality will be assured by a system of coding. We will then perform initial medical examinations and obtain routine laboratory data on all patients participating in the project. Specimens for immunologic and virologic assessment and banking will be collected and separated in the General Clinical Research Center (GCRC). This data and that obtained in scheduled follow- up visits will be entered into the GCRC's CLINFO database in sequential fashion over the entire duration of the study. This database will define the natural history of HIV infection in our population. Based on the initial clinical and laboratory studies, patients and specimens will be triaged to specific protocols (Projects 2, 3 and 5) which will evaluate therapeutic interventions of HIV infection or study basic questions concerning the pathogenesis of AIDS. Patients will have rapid access to state-of- the-art medical care. When they develop opportunistic infections, they will be enrolled in therapeutic protocols, if available, or treated with standard therapy. All information will be included in the database.