ESTABLISHMENT OF A COHORT AND CLINICAL MANAGEMENT

我们将招募大量的艾滋病毒感染者， 疾病的各个阶段，通过联系医生，适当 医疗、公共卫生和社区组织。 都有 已经给予书面同意，鼓励患者 参与该项目。 将获得同意， 招募和临床和实验室数据的收集。 保密性将通过编码系统得到保证。 我们将 然后进行初步体检， 参与该项目的所有患者的实验室数据。 用于免疫学和病毒学评估和建库的标本 将在一般临床研究中收集和分离 中心（GCRC）。 这些数据和在预定时间内获得的数据如下- 随访将被输入GCRC的BAPFO数据库， 在整个研究期间以顺序方式进行。 这 数据库将定义我们的艾滋病毒感染的自然史， 人口 根据最初的临床和实验室研究， 患者和标本将根据特定方案进行分类 （项目2、3和5），将评估治疗干预措施 艾滋病毒感染或研究有关艾滋病的基本问题 艾滋病的发病机制。 患者可以快速获得... 最先进的医疗服务 当他们出现机会性感染时， 他们将被纳入治疗方案（如果可用），或 接受标准治疗 所有信息都将包含在 数据库

We will recruit a large population of HIV infected individuals in various stages of disease by contacting physicians, appropriate medical, public health and community organizations. All have already given written agreement to encourage patients to participate in the project. Consent will be obtained for enrollment and the collection of clinical and laboratory data. Confidentiality will be assured by a system of coding. We will then perform initial medical examinations and obtain routine laboratory data on all patients participating in the project. Specimens for immunologic and virologic assessment and banking will be collected and separated in the General Clinical Research Center (GCRC). This data and that obtained in scheduled follow- up visits will be entered into the GCRC's CLINFO database in sequential fashion over the entire duration of the study. This database will define the natural history of HIV infection in our population. Based on the initial clinical and laboratory studies, patients and specimens will be triaged to specific protocols (Projects 2, 3 and 5) which will evaluate therapeutic interventions of HIV infection or study basic questions concerning the pathogenesis of AIDS. Patients will have rapid access to state-of- the-art medical care. When they develop opportunistic infections, they will be enrolled in therapeutic protocols, if available, or treated with standard therapy. All information will be included in the database.