ESTABLISHMENT OF A COHORT AND CLINICAL MANAGEMENT

队列的建立和临床管理

• 批准号: 3803643
• 负责人: MICHAEL F PARA
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3803643
• 关键词: AIDS; disease /disorder classification; epidemiology; human immunodeficiency virus 1; human subject; information systems; patient /disease registry; questionnaires

We will recruit a large population of HIV infected individuals in various stages of disease by contacting physicians, appropriate medical, public health and community organizations. All have already given written agreement to encourage patients to participate in the project. Consent will be obtained for enrollment and the collection of clinical and laboratory data. Confidentiality will be assured by a system of coding. We will then perform initial medical examinations and obtain routine laboratory data on all patients participating in the project. Specimens for immunologic and virologic assessment and banking will be collected and separated in the General Clinical Research Center (GCRC). This data and that obtained in scheduled follow- up visits will be entered into the GCRC's CLINFO database in sequential fashion over the entire duration of the study. This database will define the natural history of HIV infection in our population. Based on the initial clinical and laboratory studies, patients and specimens will be triaged to specific protocols (Projects 2, 3 and 5) which will evaluate therapeutic interventions of HIV infection or study basic questions concerning the pathogenesis of AIDS. Patients will have rapid access to state-of- the-art medical care. When they develop opportunistic infections, they will be enrolled in therapeutic protocols, if available, or treated with standard therapy. All information will be included in the database.

我们将招募大量艾滋病毒感染者 通过联系医生，了解疾病的各个阶段，适当 医疗、公共卫生和社区组织。 都有 已经给出书面协议，鼓励患者 参与该项目。 将获得同意 登记以及临床和实验室数据的收集。 保密性将通过编码系统来保证。 我们将 然后进行初步体检并获得常规检查 参与该项目的所有患者的实验室数据。 用于免疫学和病毒学评估和储存的样本 将在一般临床研究中收集和分离 中心（GCRC）。 这些数据以及在预定的后续中获得的数据 访问量将被输入 GCRC 的 CLINFO 数据库 整个研究期间的顺序时尚。 这 数据库将定义我们的艾滋病毒感染的自然史 人口。 根据初步的临床和实验室研究， 患者和标本将按照特定方案进行分类 （项目 2、3 和 5）将评估治疗干预措施 HIV 感染或研究有关 HIV 感染的基本问题 艾滋病的发病机制。 患者将能够快速进入状态 最先进的医疗服务。 当他们出现机会性感染时， 他们将参加治疗方案（如果有），或者 采用标准疗法进行治疗。 所有信息将包含在 数据库。