ENHANCING FUNCTIONAL PLASTICITY AFTER CEREBRAL ISCHEMIA

护士在照顾头部受伤的幸存者方面发挥着关键作用 残留的神经和认知缺陷 头部受伤是一个重大的 公共卫生问题。 脑缺血是最常见的原因， 严重头部创伤后的继发性脑损伤 临床条件 通常由脑缺血引起是学习和记忆 尤其是空间记忆力的缺失。 这些改变的 认知状态被认为是受环境影响的 操纵 认识到外部环境的影响 可塑性（神经元通路的再生）在发展和正常 动物和人类支持可塑性可以增强的假设， 脑损伤后 对环境的探索 诱导学习等可塑性事件。 然后假设， 功能可塑性（具有行为结果的可塑性）可以被诱导 通过操纵外部环境并以动物为模型。 这 一项研究将探讨丰富外部环境对 功能可塑性 缺血性损伤后，将成年动物 暴露于富集环境或标准（饲养笼）条件。 之后，他们将接受空间学习任务的测试。 在莫里斯水迷宫中寻找道路。 此外，性别差异 将被审查。 从本研究中获得的知识将作为 脑缺血治疗的发展指南 损害

Nurses assume a key role in caring for survivors of head injury who have residual neurological and cognitive deficits. Head injury is a major public health problem. Cerebral ischemia is the most common cause of secondary brain injury after severe head trauma. Clinical conditions that commonly result from cerebral ischemia are learning and memory impairment, particularly spatial memory deficits. These altered cognitive states are believed to be amenable to environmental manipulations. The realization that the external environment influences plasticity (regeneration in neuronal pathways) in developing and normal animals and humans support the assumption that plasticity can be enhanced following brain damage. Exploration of the environment has been known to induce plastic events such as learning. It is then hypothesized that functional plasticity (plasticity with behavioral outcome) can be induced by manipulating the external environment and modeled in animals. This study will examine the effects of enriching the external environment on functional plasticity. Following ischemic injury, adult animals will be exposed to either enriched environment or standard (home cage) condition. After that they will then be tested on a spatial learning task (wayfinding) in the Morris water maze. In addition, gender differences will be examined. The knowledge acquired from this study will serve as a guide in developing therapies in the management of ischemic brain damage.