OccuLook - a non-invasive blood glucose meter for diabetes care

OccuLook - 用于糖尿病护理的无创血糖仪

• 批准号: 48572
• 金额: $ 18.39万
• 依托单位: OCCUITY LTD
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=48572
• 关键词: OccuLook; non; invasive; blood; glucose

Diabetes is a long-term disease that occurs when the pancreas stops making insulin or when the body cannot effectively use the insulin that is produced. People with diabetes have an increased risk of developing serious health problems including heart disease, blindness, kidney failure and lower limb amputationDiabetes is increasing at an alarming rate throughout the world. The International Diabetes Federation says that 463 million people now live with the condition and that number will grow to 700 million by 2045\. According to Public Health England there are currently 4.5 million people in the UK with diabetes and the cost of treatment is £10 billion per year; nearly 10 per cent of the NHS's entire budget.Self-monitoring of blood glucose is essential to maintain healthy glucose levels. The main method involves pricking the finger with a needle and putting the blood obtained on a test strip. Worldwide more than 44 million tests are performed daily, at a global cost of over $14 billion per annum. By making these measurements patients are able to adjust their diet and medication.Despite the measurement need, the finger stick method is widely disliked as:* It is invasive and carries the risk of infection* Continuous pricking of the fingers causes hard skin* The process is not pain free* It has an ongoing cost of around £400 per patient per year.The purpose of this project is therefore to develop a non-invasive meter that will replace finger sticks. The instrument will overcome the problems highlighted above by using light to analyse the fluid in the eye. This fluid is primarily blood serum so has a glucose composition directly related to that of blood and, as the eye is transparent, it is possible to measure it optically.The Occuity team have previously developed prototype meters and performed clinical trials that gave very promising results. The previous measurement technique, however, looked at an effect of glucose changes on the eye and was subject to variability due to other changes. A new technique has now been invented that measures direct changes of glucose level and therefore has the potential to be significantly more accurate. The purpose of this initial project phase, for which a SMART grant is being requested, is to review market and user needs, build a prototype meter that uses this new technique and to prepare for a clinical evaluation.

糖尿病是一种长期疾病，当胰腺停止分泌胰岛素或身体不能有效利用所产生的胰岛素时，就会发生糖尿病。糖尿病患者罹患严重健康问题的风险增加，包括心脏病、失明、肾衰竭和截肢。糖尿病在全世界正以惊人的速度增长。国际糖尿病联合会表示，目前有4.63亿人患有这种疾病，到2045年，这一数字将增长到7亿。根据英国公共卫生组织的数据，目前英国有450万糖尿病患者，每年的治疗费用为100亿GB，几乎占NHS全部预算的10%。自我监测血糖对保持健康的血糖水平至关重要。主要的方法是用针刺破手指，并将获得的血液放在试纸上。全世界每天进行的测试超过4400万次，全球每年的费用超过140亿美元。通过进行这些测量，患者能够调整他们的饮食和药物。尽管需要测量，但手指棒法普遍不受欢迎，因为：*它是侵入性的，有感染的风险*手指连续刺痛会导致皮肤变硬*这个过程并不是没有疼痛*它的持续成本约为每位患者每年400 GB。因此，该项目的目的是开发一种将取代手指棒的非侵入性测量仪。该仪器将克服上述突出的问题，通过使用光来分析眼睛中的液体。这种液体主要是血清，因此其葡萄糖成分与血液中的葡萄糖成分直接相关，由于眼睛是透明的，因此可以用光学方法进行测量。Occuity团队之前已经开发了样机，并进行了临床试验，取得了非常有希望的结果。然而，以前的测量技术着眼于血糖变化对眼睛的影响，并受其他变化的影响。现在已经发明了一种新技术，可以测量血糖水平的直接变化，因此有可能明显更准确。这一初始项目阶段的目的是审查市场和用户需求，建造使用这一新技术的原型仪表，并为临床评估做准备。