Mathematical Modelling of the Mechanobiology of Arterial Plaque Growth

动脉斑块生长力学生物学的数学模型

• 批准号: DP200103492
• 负责人: Prof Zhi-Yong Li
• 金额: $ 29.49万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103492
• 关键词: Mathematical; Modelling; Mechanobiology; Arterial; Plaque

Plaque growth is a chronic inflammatory response induced by the interactions between endothelial cells, lipids, monocytes/macrophages, smooth muscle cells and platelets in the arteries. It involves many different biological processes, such as lipid deposition, inflammation and angiogenesis, and their interactions with the microcirculation. To understand the underlying mechanobiology, we propose to develop a mathematical model to interpret plaque growth by integrating these dynamic biological processes. It will offer a systematic rational understanding of plaque growth. New models will be provided to better interpret biological data and contribute to our knowledge in quantifying complex biological mechanisms during growth and development.

斑块生长是动脉内皮细胞、脂质、单核/巨噬细胞、平滑肌细胞和血小板相互作用所引起的慢性炎症反应。它涉及许多不同的生物学过程，如脂质沉积、炎症和血管生成，以及它们与微循环的相互作用。为了理解潜在的机制生物学，我们建议开发一个数学模型来解释斑块的生长，通过整合这些动态的生物过程。它将为斑块的生长提供一个系统的理性理解。将提供新的模型来更好地解释生物学数据，并有助于我们在量化生长和发育过程中复杂的生物学机制方面的知识。