Imaging-based fluid-structure interaction modelling of carotid atherosclerotic plaque

基于成像的颈动脉粥样硬化斑块流固耦合模型

• 批准号: FT140101152
• 负责人: Prof Zhi-Yong Li
• 金额: $ 53.1万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-05-12 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140101152
• 关键词: Imaging; based; fluid; structure; interaction

This project aims to combine computational modelling, magnetic resonance imaging (MRI), mechanical measurement and pathological analysis to investigate carotid plaque progression, and quantify the critical blood flow and plaque stress/strain conditions under which plaque rupture is likely to occur. MRI-based 3D computational models with multi-component plaque structures and their interaction with blood flow will be developed and solved numerically to identify suitable plaque rupture risk indicators. Mechanical properties of plaque components will be measured ex-vivo and fibre orientation-based constitutive rules will be developed. This project aims to lead to quantitative understandings of plaque progression and rupture.

本项目旨在结合联合收割机、磁共振成像（MRI）、力学测量和病理分析来研究颈动脉斑块进展，并量化斑块破裂可能发生的临界血流和斑块应力/应变条件。将开发基于MRI的多组分斑块结构及其与血流相互作用的三维计算模型，并通过数值求解来确定合适的斑块破裂风险指标。将在体外测量斑块组件的机械性能，并开发基于纤维取向的本构规则。该项目旨在导致斑块进展和破裂的定量理解。