REGULATION OF MACROPHAGE INTERLEUKIN 1 BETA PRODUCTION

HIV-1感染者经常出现细菌性肺部感染， 感染，甚至在疾病的早期。 本研究者 正在研究参与加工和分泌的分子事件 白细胞介素1 β从人类单核细胞和肺泡巨噬细胞。 白细胞介素1 β在脓毒症诱导的休克中具有重要作用， 肺组织损伤 白细胞介素1b可以促进和维持 炎症通过其对许多组织的有效作用。 例如IL-1b 诱导血管内皮细胞显示整合素，触发中性粒细胞 激活和迁移，信号间充质细胞增殖， 启动细胞因子如IL-6和IL-8的二级级联反应。 因此 IL-1b近端控制可能随后的炎症事件。

Individuals with HIV-1 infection experience frequent bacterial pulmonary infections, even early in the course of their disease. This investigator is studying the molecular event involved in the processing and secretion of interleukin 1 beta from human monocytes and alveolar macrophages. Interleukin 1 beta has an important role in sepsis induced shock and pulmonary tissue injury. Interleukin 1b can promote and maintain inflammation via its potent effects on many tissues. For example IL-1b induces vascular endothelium to display integrins, triggers neutrophils to activation and migration, signals mesenchymal cells to proliferate and initiates a secondary cascade of cytokines such as IL-6 and IL-8. Thus IL-1b proximally controls may subsequent inflammatory events.