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NOVEL ORGANIC REAGENTS FOR BIOMEDICAL APPLICATIONS

NOVEL ORGANIC REAGENTS FOR BIOMEDICAL APPLICATIONS
用于生物医学应用的新型有机试剂
批准号：
2224702
负责人：
Ramachandra S Hosmane
金额：
$12.51万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-09-30 至 1996-08-31
来源：
https://reporter.nih.gov/project-details/2224702
关键词：
blood /plasma substitute chemical binding chemical structure function chemical synthesis drug design /synthesis /production oxygen tension oxygen transport oxyhemoglobin

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中文摘要
翻译
这些研究人员建议设计和合成一系列 含有带负电荷的官能团的双官能有机试剂 基团和特定分子系链长度的范围。 这些 双功能有机试剂用于化学修饰无细胞的 用作携氧血液代用品的人血红蛋白 紧急输血 这些人造氧载体将免费 艾滋病毒和其他输血传播的传染性病原体。 的 研究人员将验证分子结构配置， 新合成试剂的构象和系链长度，然后 探索试剂与天然氨基形成共价键的潜力 酸赖氨酸半胱氨酸缬氨酸在水介质中。 修饰的血红蛋白 它们的物理组成和功能特性 将被调查。
英文摘要
These investigators propose to design and synthesize a series of bifunctional organic reagents which contain negatively charged functional groups and range of specific molecular tether lengths. These bifunctional organic reagents are for chemically modifying cell-free human hemoglobins for use as oxygen carrying blood substitutes in emergency transfusions. These artificial oxygen carriers would be free of HIV and other transfusion-transmitted infectious agents. The investigators will verify molecular structures configuration, conformation and tether length of the newly synthesized reagents and then explore the reagents' potential to form covalent bonds with natural amino acids lysine cysteine valine in aqueous media. The modified hemoglobins will be purified and their physical composition and functional properties will be investigated.
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Mechanistic Studies of Anti-HIV Activity of a Novel Ring-Expanded Nucleoside
Mechanistic Studies of Anti-HIV Activity of a Novel Ring-Expanded Nucleoside
Mechanistic Studies of Anti-HIV Activity of a Novel Ring-Expanded Nucleoside
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