ANTITHROMBOTIC PEPTIDE RELEASE FROM NEW BIOMATERIALS

新生物材料释放抗血栓肽

• 批准号: 2227905
• 负责人: THOMAS Alan HORBETT
• 金额: $ 14.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-15 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2227905
• 关键词: animal tissue; antithrombins; antithrombogenic surface; biomaterial development /preparation; blood coagulation; blood coagulation tests; drug vehicle; human tissue; peptides; pharmacokinetics; polymers; slow release drug

Novel biomaterials that release a controlled dose of an anti-thrombotic peptide into the blood will be prepared. These biomaterials should be more biocompatible because they inhibit coagulation in the region it is likely to occur, namely at the blood polymer interface. A low temperature glow discharge plasma deposition technology will be used to form very thin, crosslinked coatings that limit the rate of release of a peptide incorporated into the underlying material. Variations in the coating conditions will allow us to prepare materials that release various peptides at the desired rate. Besides anti-thrombotics, other peptides of biomedical usefulness could be delivered in this way because this is a somewhat general method that is not specific to the particular peptide/polymer pair.

释放受控剂量的抗血栓药物的新型生物材料 进入血液中的多肽将被制备。这些生物材料应该更多地 生物相容，因为它们很可能抑制该区域的凝血 发生，即在血液聚合物界面。低温光芒 将使用放电等离子沉积技术来形成非常薄的， 限制多肽释放速率的交联型涂层 结合到底层材料中。涂层的变化 条件允许我们准备释放各种物质的材料 以所需的速率合成多肽。除抗血栓药外，其他的多肽 生物医学的有用性可以通过这种方式提供，因为这是一种 某种不特定于特定事物的一般性方法 多肽/聚合物对。