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EFFECT OF SURFACE CHEMISTRY & ADHESION PROTEINS ON PROCOAGULANT ACTIVITY: BLOOD

EFFECT OF SURFACE CHEMISTRY & ADHESION PROTEINS ON PROCOAGULANT ACTIVITY: BLOOD
表面化学的影响
批准号:
6345061
负责人:
THOMAS Alan HORBETT
金额:
$0.49万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-01 至 2001-08-31

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项目成果

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中文摘要
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英文摘要
The effect of material contact and adhesion proteins on induction of the procoagulant state in platelets is being investigated. The substrates used are Immulon I, untreated 96-well microtiter plates and C3F6 RFGD plasma-coated Immulon I plates. Surfaces are preadsorbed with normal or depleted (missing Fg, Fn, or both) plasma and then exposed to the platelet-containing solution. Adherent platelets are incubated with a mixture of Va, Xa, and prothrombin in PSB. Thrombin generation is stopped at the time points of the study by the addition of EDTA. ESCA is used to characterize the composition and chemistry of the substrates.
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Ultralow Protein Adsorption Hemocompatible Biomaterials
  • 批准号:
    6770157
  • 项目类别:
  • 资助金额:
    $23.45万
  • 财政年份:
    2001
  • 负责人:
    THOMAS Alan HORBETT
  • 依托单位:
Ultralow Protein Adsorption Hemocompatible Biomaterials
  • 批准号:
    6538062
  • 项目类别:
  • 资助金额:
    $24.81万
  • 财政年份:
    2001
  • 负责人:
    THOMAS Alan HORBETT
  • 依托单位:
Ultralow Protein Adsorption Hemocompatible Biomaterials
  • 批准号:
    6361613
  • 项目类别:
  • 资助金额:
    $22.8万
  • 财政年份:
    2001
  • 负责人:
    THOMAS Alan HORBETT
  • 依托单位:
Ultralow Protein Adsorption Hemocompatible Biomaterials
  • 批准号:
    6638804
  • 项目类别:
  • 资助金额:
    $23.45万
  • 财政年份:
    2001
  • 负责人:
    THOMAS Alan HORBETT
  • 依托单位: