NEUROLOGY OF NOVELTY-SEEKING BEHAVIOR AND CURIOSITY

求新行为和好奇心的神经学

• 批准号: 2241031
• 负责人: KIRK R DAFFNER
• 金额: $ 14.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2241031
• 关键词: association cortex; attention; brain electrical activity; brain imaging /visualization /scanning; electroencephalography; evoked potentials; exploratory behavior; eye movements; frontal lobe /cortex; human subject; magnetic resonance imaging; neural information processing; neuroanatomy; neuropsychological tests; parietal lobe /cortex; saccades; stimulus /response; stroke; video recording system; visual fixation; visual perception; visual stimulus

Orienting to novelty plays a critical role in directing attention and guiding behavior in normal individuals and is disrupted in many disease states. Yet, little is known about the neural substrate of novelty seeking. The proposed research will investigate the neuroanatomical and electrophysiological underpinning of responses to novel stimuli. Non-brain damaged subjects will be studied to determine the link between early stages of C.N.S. responses to novel stimuli using electrophysiological recordings (as measured by the "novelty" P300) and subsequent stages of information processing and behavioral responses (as measured by subject-controlled stimulus exposure durations). Patients with strokes will be studied to investigate the impact of focal lesions on electrophysiological and behavioral components of novelty seeking and to determine if the frontal cortex plays an essential role in this activity. All subjects will be studied in 1) an Event-Related potential (ERP) Laboratory using specifically designed visual stimuli to evoke different electrophysiological responses and behavioral reactions and 2) an Eye movement Laboratory using visual stimuli to elicit exploratory eye movements. Stroke patients will undergo magnetic resonance imaging (MRI) with 3 dimensional surface reconstruction of the lesion site to precisely delineate the location of structural brain damage.

以新奇事物为导向在引导注意力和 正常个体的引导行为，在许多疾病中被扰乱 各州。然而，人们对新奇事物的神经基础知之甚少。 寻找。拟议的研究将调查神经解剖学和 对新刺激反应的电生理学基础。非脑 将对受损受试者进行研究，以确定早期阶段之间的联系 用电生理记录研究中枢神经系统对新刺激的反应 (以“新颖性”P300衡量)和随后的信息阶段 处理和行为反应(由受试者控制的测量 刺激暴露持续时间)。中风患者将被研究到 探讨局灶性病变对电生理和脑功能的影响。 寻找新颖性的行为成分，并确定额叶是否 皮质在这一活动中起着至关重要的作用。所有的科目都将是 在1)事件相关电位(ERP)实验室中使用 专门设计的视觉刺激，以唤起不同的 电生理反应和行为反应和2)眼睛 利用视觉刺激引发探索性眼睛的运动实验室 动静。中风患者将接受磁共振成像(MRI) 通过病变部位的三维表面重建来精确地 勾画出结构性脑损伤的位置。