ERP Investigations of Novelty Processing in Aging and AD

老化和 AD 中新颖性处理的 ERP 调查

• 批准号: 6883150
• 负责人: KIRK R DAFFNER
• 金额: $ 41.09万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883150
• 关键词: Alzheimer' s disease; age difference; aging; attention; behavior test; biological signal transduction; clinical research; cognition; evoked potentials; human middle age (35-64); human old age (65+); human subject; neural information processing; neurophysiology; neuropsychology; psychological concentration; young adult human (21-34)

DESCRIPTION: (provided by applicant) Attention to novel events facilitates adaptation to a changing environment and may increase engagement with one?s surroundings and enhance cognitive abilities. Despite its importance, there has been limited study of age- and disease-related changes in how the brain processes novel events. Based on the PI?s research, a provisional model of a neurally-based novelty processing system is presented. Building upon this work, the proposed research will investigate age-related changes in the novelty P3 response and subsequent allocation of attention to novel stimuli (as measured by viewing durations) in order to elucidate the relationship between responsiveness to novelty and different patterns of cognitive aging. The research aims to distinguish between changes in response to novelty that appear to be inevitable (observed with even the most successful cognitive aging), changes that are most commonly seen with usual cognitive aging, and changes that are associated with the most frequent degenerative disease of the brain (Alzheimer?s disease). A carefully designed series of experiments will test hypotheses about: 1) age-related changes in response to novelty among groups of cognitively high performing individuals; 2) differences in response to novelty between cognitively high and mid performing older individuals; 3) age-related changes in response to novelty among groups of individuals that differ in level of cognitive performance; 4) differences in response to novelty between cognitively normal individuals and cognitively impaired ones (with mild Alzheimer?s disease); and 5) the relationship between the novelty P3 response and subsequent attention to novel events in the laboratory and level of engagement in daily activities. These integrative functional and cognitive neuroscientific studies will extend previous work on the neurology of attention to novel events and provide new insights into the ways in which this fundamental aspect of human behavior is related to normal aging and disease.

描述：（由申请人提供）关注新事件有助于 适应不断变化的环境，并可能增加与一个？S 环境和增强认知能力。尽管它的重要性， 对年龄和疾病相关的大脑变化的研究有限， 处理新的事件。根据PI？的研究，一个临时模型， 提出了一种基于神经网络的新奇处理系统。在这项工作的基础上， 拟议的研究将调查与年龄有关的变化，在新奇的P3 对新刺激的反应和随后的注意力分配（如测量的 通过观察持续时间），以阐明 对新奇事物的反应和认知老化的不同模式。的 研究旨在区分对新奇的反应变化， 是不可避免的（即使是最成功的认知老化观察到的）， 最常见的认知老化的变化， 与最常见的大脑退化性疾病有关 （阿尔茨海默病？的疾病）。 一系列精心设计的实验将测试以下假设：1） 认知水平高的人群对新奇事物反应的年龄相关变化 （2）对新奇事物反应的差异， 认知能力高和中等表现的老年人; 3）与年龄相关的变化 为了响应不同水平的个体群体之间的新奇感， 认知表现; 4）对新奇事物反应的差异 认知正常个体和认知受损个体（轻度 老年痴呆症？的疾病）;和5）之间的关系，新奇P3反应 以及随后对实验室中新事件的关注， 参与日常活动。这些整合的功能和认知 神经科学的研究将扩展以前在注意力神经学方面的工作 新的事件，并提供新的见解的方式， 人类行为的基本方面与正常的衰老和疾病有关。