EFFECT OF POSTURAL CHANGE IN HEART TRANSPLANT PATIENTS

体位改变对心脏移植患者的影响

• 批准号: 2258572
• 负责人: Lynn Valerie Doering
• 金额: $ 1.27万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2258572
• 关键词: autonomic reflex; blood pressure; cardiac output; denervation; electrocardiography; environmental adaptation; heart rate; heart transplantation; hemodynamics; human subject; intracardiac volume; norepinephrine; posture; vascular resistance

A consequence of orthotopic heart transplantation is permanent denervation of the donor heart. The specific aim of the proposed study, "The Effect of Orthostatic Change on Cardiovascular Stability in Orthotopic Heart Transplant Recipients" is to compare changes in cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), heart rate (HR), systemic vascular resistance (SVR), and norepinephrine (NE) levels in heart transplant recipients and in normal subjects when both are subjected to a tilt table test. The long-term objectives include determining how physiologic responses are altered when autonomic function is disrupted by cardiac denervation. Using a two-group, quasi-experimental pretest- posttest design, heart transplant recipients and age- and sex-matched normal controls will be subjected to passive tilt from horizontal to 70 degrees via a motorized tilt table. Exclusion criteria for transplant subjects include: evidence of cardiac or renal failure, fluid retention, dizziness, syncope, or orthostatic hypotension. Exclusion criteria for control subjects include: orthostatic hypotension, syncope, palpitations or any other manifestation of cardiac or endocrine dysfunction. Repeated measures of CO, SV, MAP, HR, SVR, and NE levels will be taken before, during, and after passive tilt. Data will be analyzed using repeated measures multivariate analysis of variance. Understanding how physiologic responses are altered when autonomic function is disrupted will enhance nurses' abilities to provide effective care and to promote independent activity among heart transplant recipients.

原位心脏移植的一个后果是永久性去神经

项目成果

Relationship of age, sex, and procedure type to extubation outcome after heart surgery.

年龄、性别和手术类型与心脏手术后拔管结果的关系。

• DOI: 10.1016/s0147-9563(97)90037-6
• 发表时间: 1997
• 期刊: Heart & lung : the journal of critical care.
• 作者: Doering,LV