SEVERE DEPRESSION IN WOMEN AFTER CARDIAC SURGERY

女性心脏手术后出现严重抑郁症

• 批准号: 6499206
• 负责人: Lynn Valerie Doering
• 金额: $ 12.65万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6499206
• 关键词: behavioral /social science research tag; clinical depression; clinical research; cognitive behavior therapy; coronary bypass; disease /disorder proneness /risk; female; functional ability; human subject; human therapy evaluation; immunopathology; natural killer cells; postoperative complications; quality of life; social adjustment; women's health

Women account for 27% of the estimated 573,000 coronary artery bypass (CABG) graft surgeries performed annually and suffer greater perioperative mortality and post-operative morbidity, including depression, than men. Depression is a predictor of both mortality and morbidity in other cardiac patients. It has been associated with decreased cell-mediated immunity. While depression after CABG is common, little is known about its severity or its association with post-operative outcomes, such as immune function, infectious complications, functional status, psychosocial adjustment, and quality of life. A structured cognitive behavioral intervention designed specifically to relieve depression has not been tested during early postoperative recovery of CABG patients, even though it is the therapy of choice for mild to moderate depression. The proposed research plan has two overall objectives. The first objective is to obtain evidence regarding the risk of postoperative complications associated with compromised immune function in depressed women compared to non-depressed women undergoing CABG. The second objective is to describe the application of cognitive behavioral therapy in depressed women early after CABG. The overall objective of the proposed award is to increase the applicant's knowledge in immunology and in the delivery of cognitive behavioral therapy, so that she is better equipped to pursue a research career in biobehavioral science. A 3-year training plan is proposed. The plan incorporates formal classes in immunology and cognitive behavioral therapy with laboratory training, under the direction of scientists and clinical experts, in each field. The research proposed as part of the award is designed to completed the applicant's formal and laboratory training.

女性占每年进行的估计573，000例冠状动脉旁路移植术（CABG）移植手术的27%，并且比男性遭受更高的围手术期死亡率和术后发病率，包括抑郁症。 抑郁是其他心脏病患者死亡率和发病率的预测因子。它与细胞介导的免疫力下降有关。虽然CABG术后抑郁很常见，但对其严重程度或与术后结局（如免疫功能、感染性并发症、功能状态、心理社会适应和生活质量）的相关性知之甚少。一个结构化的认知行为干预，专门设计来缓解抑郁症尚未测试在CABG患者术后早期恢复，即使它是轻度至中度抑郁症的治疗选择。拟议的研究计划有两个总体目标。第一个目的是获得证据，与非抑郁女性相比，抑郁女性接受CABG术后免疫功能受损相关的术后并发症的风险。第二个目标是描述认知行为疗法在冠状动脉旁路移植术后早期抑郁妇女中的应用。该奖项的总体目标是增加申请人在免疫学和认知行为疗法方面的知识，使她能够更好地从事生物行为科学的研究事业。提出了三年培训计划。该计划将免疫学和认知行为疗法的正式课程与实验室培训相结合，在科学家和临床专家的指导下，在每个领域进行。作为该奖项的一部分提出的研究旨在完成申请人的正式和实验室培训。

项目成果

Utility of observer-rated and self-report instruments for detecting major depression in women after cardiac surgery: a pilot study.

观察者评级和自我报告工具用于检测心脏手术后女性重性抑郁的实用性：一项试点研究。

• 发表时间: 2007
• 期刊: American journal of critical care : an official publication, American Association of Critical-Care Nurses
• 作者: Doering,LynnV;Cross,Rebecca;Magsarili,MariseC;Howitt,LorettaY;Cowan,MarieJ
• 通讯作者: Cowan,MarieJ