SEVERE DEPRESSION IN WOMEN AFTER CARDIAC SURGERY

女性心脏手术后出现严重抑郁症

• 批准号: 6052071
• 负责人: Lynn Valerie Doering
• 金额: $ 11.69万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6052071
• 关键词: behavioral /social science research tag; clinical depression; clinical research; cognitive behavior therapy; coronary bypass; disease /disorder proneness /risk; female; functional ability; human subject; human therapy evaluation; immunopathology; natural killer cells; postoperative complications; quality of life; social adjustment; women's health

Women account for 27% of the estimated 573,000 coronary artery bypass (CABG) graft surgeries performed annually and suffer greater perioperative mortality and post-operative morbidity, including depression, than men. Depression is a predictor of both mortality and morbidity in other cardiac patients. It has been associated with decreased cell-mediated immunity. While depression after CABG is common, little is known about its severity or its association with post-operative outcomes, such as immune function, infectious complications, functional status, psychosocial adjustment, and quality of life. A structured cognitive behavioral intervention designed specifically to relieve depression has not been tested during early postoperative recovery of CABG patients, even though it is the therapy of choice for mild to moderate depression. The proposed research plan has two overall objectives. The first objective is to obtain evidence regarding the risk of postoperative complications associated with compromised immune function in depressed women compared to non-depressed women undergoing CABG. The second objective is to describe the application of cognitive behavioral therapy in depressed women early after CABG. The overall objective of the proposed award is to increase the applicant's knowledge in immunology and in the delivery of cognitive behavioral therapy, so that she is better equipped to pursue a research career in biobehavioral science. A 3-year training plan is proposed. The plan incorporates formal classes in immunology and cognitive behavioral therapy with laboratory training, under the direction of scientists and clinical experts, in each field. The research proposed as part of the award is designed to completed the applicant's formal and laboratory training.

在每年约573,000例冠状动脉搭桥术(CABG)手术中，女性占27%，她们遭受的围手术期死亡率和术后发病率(包括抑郁症)比男性更高。在其他心脏病患者中，抑郁是死亡率和发病率的预测因子。它与细胞免疫功能下降有关。虽然冠状动脉旁路移植术后抑郁是常见的，但人们对其严重程度及其与术后结果的关系知之甚少，如免疫功能、感染并发症、功能状态、心理社会适应和生活质量。一种专门为缓解抑郁而设计的结构化认知行为干预在CABG患者术后早期康复期间尚未进行测试，尽管它是治疗轻度至中度抑郁症的首选方法。拟议的研究计划有两个总体目标。第一个目标是获得与接受冠脉搭桥术的非抑郁症女性相比，抑郁症女性术后并发症与免疫功能受损相关的风险的证据。第二个目标是描述认知行为疗法在CABG术后早期抑郁女性中的应用。拟议奖项的总体目标是增加申请者在免疫学和认知行为疗法方面的知识，以便她能够更好地从事生物行为科学的研究事业。提出了一个为期3年的培训计划。该计划将免疫学和认知行为疗法的正式课程与实验室培训结合起来，在每个领域的科学家和临床专家的指导下进行。作为该奖项的一部分，这项研究旨在完成申请者的正式和实验室培训。