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FUNCTION OF THE DLX GENES IN FOREBRAIN DEVELOPMENT

FUNCTION OF THE DLX GENES IN FOREBRAIN DEVELOPMENT
DLX 基因在前脑发育中的功能
批准号：
2250817
负责人：
JOHN L. R. RUBENSTEIN
金额：
$14.33万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-09-30 至 1997-08-31
来源：
https://reporter.nih.gov/project-details/2250817
关键词：
DNA binding protein developmental neurobiology fusion gene gene deletion mutation gene targeting genetically modified animals laboratory mouse prosencephalon recombinant proteins regulatory gene transcription factor transfection

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DESCRIPTION: This proposal is driven by the hypothesis that regional specification of the forebrain is largely controlled by a hierarchy of genes encoding transcriptional regulators. A large portion of the proposal depends on gene knockout technology which will be used to inactivate the Dlx-1 and Dlx-2 genes, both individually and simultaneously. The phenotype of mice that are heterozygous and homozygous for the mutations will be analyzed histologically and biochemically.
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