FUNCTION OF THE DLX GENES IN FOREBRAIN DEVELOPMENT

DLX 基因在前脑发育中的功能

• 批准号: 2250817
• 负责人: JOHN L. R. RUBENSTEIN
• 金额: $ 14.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2250817
• 关键词: DNA binding protein; developmental neurobiology; fusion gene; gene deletion mutation; gene targeting; genetically modified animals; laboratory mouse; prosencephalon; recombinant proteins; regulatory gene; transcription factor; transfection

DESCRIPTION: This proposal is driven by the hypothesis that regional specification of the forebrain is largely controlled by a hierarchy of genes encoding transcriptional regulators. A large portion of the proposal depends on gene knockout technology which will be used to inactivate the Dlx-1 and Dlx-2 genes, both individually and simultaneously. The phenotype of mice that are heterozygous and homozygous for the mutations will be analyzed histologically and biochemically.

描述：该建议是由假设驱动的， 前脑的具体化主要是由一个层次结构控制的， 编码转录调节因子的基因。的大部分 这项提案取决于基因敲除技术，该技术将用于 分别克隆Dlx-1和Dlx-2基因， 同步 杂合子小鼠的表型， 将对突变纯合子进行组织学分析， 生物化学