LONGITUDINAL STUDY OF POLYDIPSIA AND WATER INTOXICATION

烦渴和水中毒的纵向研究

• 批准号: 2250629
• 负责人: JOSE DE LEON
• 金额: $ 8.72万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2250629
• 关键词: body weight; creatinine; human subject; interview; longitudinal human study; mental disorders; psychosis; questionnaires; schizophrenia; sodium; thirst; toxicology; urinalysis; water drinking behavior

A significant proportion (3-39%) of chronic psychiatric patients have been found to drink abnormal quantities of liquids (polydipsia). Among these patients, 25 to 86% have been found to suffer from hyponatremic symptoms (water intoxication) that can entail serious neurologic and psychiatric complications, and even death. Previous prevalence studies have lacked biological measures to verify polydipsia and water intoxication. Two biological measures (diurnal weight change and specific gravity of the urine) were used to establish the prevalence of these disorders in a state hospital sample (n=360). The prevalence of both disorders using these biological measures was higher than previously reported. Little is known about the natural course of polydipsia and water intoxication. All previous studies have measured these disorders at a single point in time. A 12-month longitudinal study is proposed involving four groups of patients distinguished by severity of polydipsia and the presence of water intoxication. A second state hospital sample (n=677), already screened for these disorders, will be utilized. The goals of this proposal are to: 1) use multiple biological and behavioral measures to establish criteria for water intoxication and polydipsia (accounting for differences related to gender and race), 2) estimate the prevalence of these disorders and measure their stability, and 3) determine the demographic and clinical characteristics associated with these disorders.

很大比例（3-39%）的慢性精神病患者 被发现喝不正常数量的液体（烦渴）。 之间 这些患者中，25%至86%患有低钠血症， 症状（水中毒），可能导致严重的神经系统和 精神并发症甚至死亡 以前的流行率研究缺乏生物学措施来验证 烦渴和水中毒。 两种生物措施（昼夜 体重变化和尿比重）用于建立 这些疾病在州立医院样本中的患病率（n=360）。 使用这些生物学指标， 高于此前报道的。 人们对烦渴和水的自然过程知之甚少 中毒 所有以前的研究都是在一个 一个时间点。建议进行为期12个月的纵向研究， 四组患者按烦渴的严重程度和 存在水中毒。第二个州立医院样本（n=677）， 已经筛查过这些疾病的患者。 该提案的目标是：1）使用多种生物和 行为措施，以建立水中毒的标准， 烦渴（解释与性别和种族有关的差异），2） 估计这些疾病的患病率并测量其稳定性， 和3）确定与这些疾病相关的人口统计学和临床特征， 这些疾病。