CHEMISTRY AND BIOLOGY OF HUMAN LYMPHOCYTES

这项申请提出了与以下领域相关的研究 人类淋巴细胞的化学和生物学。正在研究的问题 涉及免疫识别的分子基础，包括 对肿瘤细胞的识别以及支配和调节的因素 人淋巴细胞的增殖。正在使用的技术包括 蛋白质化学和结晶学、分子遗传学、细胞 免疫学和病毒学。具体的研究领域包括：1)蛋白质 的化学和结晶学及其与结构的关系 I类MHC分子及其结合肽的功能，2)相似 II类MHC分子的研究，3)CD_4与CD_4的相互作用 Il类MHC分子通过其D3和D4结构域及其与蛋白质 酪氨酸激酶p56(Lck)通过其胞质内区，5)蛋白 T细胞受体化学与T细胞发育机制 细胞，6)人类白细胞抗原-C在NK同种异体识别和其他研究中的作用 细胞，7)Epstein Barr转化B、T细胞的机制 病毒；8)肿瘤坏死的表达和功能的调节 阿尔法因子。它们与肿瘤免疫学和肿瘤细胞增殖有关。 以不同的方式。

This application proposes studies in a variety of areas relating to the chemistry and biology of human lymphocytes. The problems being studied involve the molecular basis of immune recognition, including the recognition of tumor cells, as well as factors which govern and regulate proliferation of human lymphocytes. The techniques being employed include protein chemistry and crystallography, molecular genetics, cellular immunology and virology. Specific areas of investigation are: 1) protein chemistry and crystallography of and the relationship of structure to function in class I MHC molecules and their bound peptides, 2) similar studies of class II MHC molecules, 3) the interaction of CD4 with the class Il MHC molecule through its D3 and D4 domains and with the protein tyrosine kinase p56(lck) through its intracytoplasmic region, 5) protein chemistry of T cell receptors and the mechanisms of development of T cells, 6) the role of HLA-C in NK allorecognition and other studies of NK cells, 7) the mechanism of transformation of B and T cells by Epstein Barr Virus, and 8) the regulation of expression and function of tumor necrosis factor alpha. They relate to tumor immunology and tumor cell proliferation in a variety of ways.