NURSING STUDY OF PHYSICAL ACTIVITY AND WOUND HEALING
体力活动和伤口愈合的护理研究
基本信息
- 批准号:2257396
- 负责人:
- 金额:$ 8.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1994
- 资助国家:美国
- 起止时间:1994-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Twenty-three million surgical procedures are performed annually in the
United States, requiring healing of injured tissues or wounds. Failure
of wound healing contributes to morbidity, mortality and increased health
care costs resulting from longer hospital stay and increased costs of
treatment. Beyond techniques to limit wound infection, the promotion of
healing and recovery after surgery are believed to be improved by early
postoperative activity. The effect of physical activity on wound healing
and variables that are critical to repair, blood flow and oxygen levels
in peripheral tissues has not been determined. A better understanding
of how physical activity effects these factors will guide development of
clinical activity programs that promote optimal wound healing and
recovery from surgery.
The specific aims of this study are to 1) determine if augmented
postoperative activity enhances wound healing as measured by cellular and
subcellular markers of healing, 2) describe the effect of augmented
activity on subcutaneous oxygen (PscO2) and blood flow and, 3) describe
the relationships between subcutaneous perfusion/oxygen and cellular
markers of healing. Using a randomized, two group experimental design
subjects scheduled for total hip arthroplasty will participate in either
conventional postoperative activity (n=28) or a 5 day augmented
postoperative activity protocol (n=28). Wound healing will be evaluated
by analysis of tissue cellularity, mRNA for pro alpha1[I] collagen and
hydroxyproline from a tissue sample obtained from a small,
polytetrafluoroethylene tube placed subcutaneously and removed on the 7th
postoperative day. PscO2 and blood flow will be measured on the day of
surgery and the next two postoperative days with an optode/tonometer
system. Differences between groups on healing, tissue oxygen and
perfusion variables will be tested with Student's t test, ANOVA for
repeated measures, or the Mann Whitney U test depending on the level of
measurement. Relationships will be tested with Pearson's product moment
or Spearman's rank correlation coefficients.
每年有2300万例外科手术在这里进行
美国,要求愈合受伤的组织或伤口。失败
伤口愈合的风险导致发病率、死亡率和健康水平的提高
住院时间延长和医疗费用增加导致的护理成本
治疗。除了限制伤口感染的技术之外,推广
手术后的愈合和恢复被认为是早期改善的
术后活动度。体力活动对伤口愈合的影响
以及对修复、血流量和氧气水平至关重要的变量
在外周组织中的含量尚未确定。更好地理解
体力活动如何影响这些因素将指导
临床活动计划,促进最佳伤口愈合和
手术后的康复。
这项研究的具体目的是1)确定是否扩大
术后活动促进创面愈合的细胞和
愈合的亚细胞标记物,2)描述增强的效果
皮下氧气活性(PscO2)和血流量,以及,3)描述
皮下灌注/氧与细胞的关系
是治愈的标志。采用随机两组实验设计
计划进行全髋关节置换术的受试者将参加任何一项
术后常规活动(n=28)或延长5天
术后活动方案28例。将对伤口愈合情况进行评估
通过对组织细胞密度的分析,α1[I]前胶原和
从组织样本中提取的羟脯氨酸来自一种小的,
皮下放置聚四氟乙烯管7日拔除
术后一天。PscO2和血流量将在
手术和术后两天使用视力计/眼压计
系统。不同组间在愈合、组织氧和
血流灌注变量将用学生t检验,方差分析用于
重复测量,或Mann Whitney U检验,取决于
测量。关系将用培生的产品时刻来检验
或斯皮尔曼的等级相关系数。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOANNE D WHITNEY其他文献
JOANNE D WHITNEY的其他文献
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{{ truncateString('JOANNE D WHITNEY', 18)}}的其他基金
Local Warming: Effects on Wound Infection and Healing
局部变暖:对伤口感染和愈合的影响
- 批准号:
6928298 - 财政年份:2005
- 资助金额:
$ 8.62万 - 项目类别:
Local Warming: Effects on Wound Infection and Healing
局部变暖:对伤口感染和愈合的影响
- 批准号:
7121561 - 财政年份:2005
- 资助金额:
$ 8.62万 - 项目类别:
Local Warming: Effects on Wound Infection and Healing
局部变暖:对伤口感染和愈合的影响
- 批准号:
7257232 - 财政年份:2005
- 资助金额:
$ 8.62万 - 项目类别:
NURSING STUDY OF PHYSICAL ACTIVITY AND WOUND HEALING
体力活动和伤口愈合的护理研究
- 批准号:
2257397 - 财政年份:1994
- 资助金额:
$ 8.62万 - 项目类别:
NURSING STUDY OF PHYSICAL ACTIVITY AND WOUND HEALING
体力活动和伤口愈合的护理研究
- 批准号:
2460411 - 财政年份:1994
- 资助金额:
$ 8.62万 - 项目类别:
NURSING STUDY OF PHYSICAL ACTIVITY AND WOUND HEALING
体力活动和伤口愈合的护理研究
- 批准号:
2750725 - 财政年份:1994
- 资助金额:
$ 8.62万 - 项目类别:
NURSING STUDY OF PHYSICAL ACTIVITY AND WOUND HEALING
体力活动和伤口愈合的护理研究
- 批准号:
2257398 - 财政年份:1994
- 资助金额:
$ 8.62万 - 项目类别: