NEW REAGENTS AND MATERIALS FROM HIGHLY REACTIVE METALS

来自高活性金属的新试剂和材料

• 批准号: 2187618
• 负责人: REUBEN D RIEKE
• 金额: $ 48.18万
• 依托单位: RIEKE METALS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-15 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2187618
• 关键词: calcium; chemical synthesis; copper; magnesium; method development; organometallic compounds; reagent /indicator; zinc

The principal investigator notes that the primary long-term objective of the research plan will be the large scale production of novel organometallic reagents prepared from highly reactive Rieke metals. Primary metals to be examined include zinc, magnesium, copper, and calcium. It is stated that the development of highly reactive Rieke metals allows the direct oxidative addition of these metals to a variety of carbon-halogen bonds to yield many classes of organometallic reagents which previously could not be prepared and that in particular, highly functionalized organozinc and organocopper reagents are now possible. It is noted that highly reactive magnesium allows the preparation of difficult-to-prepare Grignards and a highly significant new organometallic class of reagents: (2-butene-1,4-diyl)magnesium reagents. The principal investigator reports that highly reactive calcium can be used for the generation of calcium derivatized polymers and novel organocalcium reagents. The organozinc, organocopper, and 1,3-butadiene magnesium complexes have considerable potential in the synthesis of a wide range of drugs, drug delivery system, agrochemicals, novel membranes, and polymers including highly conducting polymers.

首席调查员指出，主要长期目标是 研究计划将是小说的大规模生产 由高活性Rieke金属制备的有机金属试剂。 接受检查的主要金属包括锌、镁、铜和 钙。指出了高反应性Rieke的发展 金属允许将这些金属直接氧化加成到各种金属中 碳卤键合成多种有机金属试剂 这是以前无法准备的，特别是高度 官能化的有机锌和有机铜试剂现在是可能的。它 值得注意的是，高活性镁允许制备 难以准备的格利格纳德和一个非常重要的新 有机金属类试剂：(2-丁烯-1，4-二基)镁试剂。 主要研究人员报告说，高活性钙可以 用于生成钙衍生物聚合物和新型 有机钙试剂。有机锌、有机铜和1，3-丁二烯 镁配合物在合成有机化合物方面具有很大的潜力。 广泛的药物、药物输送系统、农用化学品、新型 膜和聚合物，包括高导电性聚合物。